UNDERSTANDING METABOLIC PATHWAYS FOR SKIN ANTI-AGING.
- TR Number: 634
- Authors: Osborne, R., Mullins, L.A., and Jarrold, B.B. P&G Beauty & Grooming, The Procter & Gamble Company, Miami Valley Innovation Center, Cincinnati, Ohio USA.
- Materials Tested: Hexamidine, N-acetylglucosamine, Niacinamide, Palmitoyl-KTTKS pentapeptide
Global gene expression profiling provides a useful means to identify key aspects of the skin aging process, and provides Information to help develop new skin technologies. Important aspects of skin aging that can be addressed Include skin hydration, barrier, matrix, pigmentation and antioxidant capacity. Human skin equivalent cultures allow topical application of test compounds, combinations and products to their stratum corneum surface and measurement of predictive biomarkers. Using this In vitro biomarker approach, it is possible to detect skin barrier enhancement In response to the compounds niacinamide and hexamidine, matrix effects to the peptldes Pal-KT and Pal-KTTKS, and hydration and matrix responses to niacinamide and N-acetylglucosamine.
Reference Application
- Inflammation
- Asthma
- Skin corrosion Absorption
- Mucosal
- Oral candidiasis
- Skin lightening
- Organ-on-a-Chip
- Oxidative Stress
- Oral inflammation
- Collagen Remodeling
- Hyperpigmentation
- Barrier Function
- Microbial infection
- COPD
- Smoking
- Respiratory toxicity
- Oral irritation
- Skin
- Oral Disease Research
- Skin Damage
- Ocular toxicology
- Drug Screening
- Skin de-pigmentation
- Gastrointestinal Toxicity
- Wound healing
- Smoke
- Tobacco
- Inhalation Toxicology
- Oral mucositis
- Smoker
- Space Research
- Skin Barrier
- Validation
- Nephrotoxicity
- Cancer Research
- Skin Brightening
- Phototoxicity
- Research
- Drug development
- Nanoparticles
- Skin pigmentation
- Gingivitis
- Dry Eye
- Drug Metabolism
- Biofilm
- Hepatotoxicity
- Personalized Medicine
- Food Additives
- UV radiation
- Basic cutaneous research
- Epithelial restitution
- Microbial
- Pigmentation
- Transbuccal permeation/penetration
- Micronucleus Assay
- Skin aging
- Intestinal barrier
- Liver Toxicity
- Consumer products
- Anti-aging
- Basic DC research
- Eye irritation
- Microbicide
- Pigmentation studies
- Oral mucosa
- microbiome
- Skin disease
- SARS-CoV-2
- Skin Toxicity
- Cytotoxicity
- Skin hydration
- UV
- Genetic toxicology
- Microbicide testing
- Radiation
- Tumor invasion
- Probiotic
- Intestinal infection
- Skin re-epithelization
- Crohn's Disease
- Inflammatory response
- UV toxicity
- Basic respiratory research
- Genomics
- STD infection
- Reproducibility - eye (ocular) tissue model
- UV light
- Irritation>Eye Irritation OECD TG 492
- Skin differentiation
- Barrier repair
- Inflamed Bowel Disease
- Visible Light
- Absorption
- Antimicrobial
- Buccal delivery
- Genotoxicity
- Mucosal delivery
- Reproducibility - skin tissue models
- UV protection
- Corneal Drug Delivery
- UV damage
- transporters
- Regulatory Approval
- Review Article
- Drug delivery
- Infectious disease research
- Buccal drug delivery
- Pharmacotoxicology
- Nasal absorption
- Nanotechnology
- Aging
- Respiratory Disease
- Bacterial infection
- Pollution
- Mildness Testing
- Barrier Disruption
- Irritation
- Infection
- Mucosal irritation
- Psoriasis
- Vaginal irritation
- Respiratory immunotoxicity
- Human-on-a-chip
- Atopic Dermatitis
- DNA Damage
- Colitis
- Drug ADME
- Hair Growth
- Permeation
- Infections
- Cosmetics
- Metabolism
- Mucous
- Respiratory infection
- Viral Infection
- Melanogenesis
- Antiviral
- Gastrointestinal Disease
- Hazard assessment
- Biomedical Devices
- Skin irritation
- Toxicity
- Cytokine analysis
- Immulogical research
- Nanoparticle toxicology/penetration
- Respiratory toxicology
- MMPs
- Intestinal Permeation
- Bacterial colonization
- Translational toxicology
- Dry skin
- drug skin compatibility
- Allergenicity
- Antioxidants
- Drug absorption
- Immunologicaal research
- Toxicology
- Skin cancer
- Photoaging
- Electrolyzed Water
- Transbuccal drug delivery
- XtraMild skin mildness testing
- Skin moisturization
- Protein Expression
- Immunological Research
- Apoptosis
- Intestinal toxicity
- Microbicides
- Nanotoxicology
- Skin corrosion
- Skin Sensitization
- Fibrosis
- Oral Pathology
- bacterial vaginosis
- ADME
- Gastrointestinal Inflammation
- Immunogenicity
- Basic dermal research
- Respiratory research
- Immunotoxicity
- Ocular irritation
- Penetration
- Medical Devices
- Pulmonary Fibrosis
- Oral infection
- vaginal microbiome
- Microphysiological system
- Gastrointestinal Irritation
Reference Product
Ready to advance your science?
Our team is ready to provide a cost-free consultation to determine how we can help you reach your research and testing goals. Contact our team of experts today.