July 20, 2023
Evaluation of in vitro rat and human airway epithelial models for acute inhalation toxicity testing
RatAir was developed to allow a direct comparison with EpiAirway to address interspecies variability in responses to harmful agents.
Reference Libraries
July 3, 2023
Optimization and Characterization of Novel ALCAM-Targeting Antibody Fragments for Transepithelial Delivery
Activated leukocyte cell adhesion molecule (ALCAM) is a cell adhesion molecule that supports T cell activation, leukocyte migration, and (lymph)angiogenesis and has been shown to contribute to the pathology of various immune-mediated disorders, including asthma and corneal graft rejection. In... Read More
June 16, 2023
Multi Species 3D Airway Tissue Models for Translational Inhalation Toxicity Studies
Scalable, reproducible in vitro 3-dimensional organotypic models from different species are needed for translational studies to develop reliable alternatives to traditional in vivo animal inhalation toxicity tests. The aim of this study is to compare toxicity responses of 3D airway... Read More
June 16, 2023
Reconstructed human intestinal comet assay, a possible alternative in vitro model for genotoxicity assessment
The aim of the present study was to evaluate the compatibility of reconstructed 3D human small intestinal microtissues to perform the in vitro comet assay. The comet assay is a common follow-up genotoxicity test to confirm or supplement other genotoxicity... Read More
June 16, 2023
Use of In Vitro Human Skin Models to Assess Potential Immune Activation In Response to Biotherapeutic Attributes and Process-related Impurities
Subcutaneous (SubQ) injection is a common administration route for biotherapeutics. However, limited tools are available for understanding the dynamic relationships between drug products and resident cells following injection. Advances in tissue engineering have enabled the production of in vitro skin... Read More
