comet assay

Advancing dermal genotoxicity assessment with RSMN and RS Comet in human 3D skin models

Standard in vitro genotoxicity assays are essential for hazard identification but may generate positive findings that are not confirmed in vivo. This represents a particular challenge for cosmetic ingredients and other dermally applied substances for which animal follow-up testing is prohibited, restricted, or scientifically undesirable. Three-dimensional reconstructed human skin models provide human-derived tissue architecture, barrier […]