Pigmentation Studies

The Model

MatTek’s MelanoDerm™ System consists of normal, human-derived epidermal keratinocytes (NHEK) and melanocytes (NHM) which have been cultured to form a multilayered, highly differentiated model of the human epidermis. The NHM within co-cultures undergo spontaneous melanogenesis leading to tissues of varying levels of pigmentation. The tissues are produced using serum free medium without artificial stimulators of melanogenesis such as TPA and IBMX. The cultures are grown on cell culture inserts at the air-liquid interface, allowing for topical application of skin lighteners or self-tanning agents, providing a useful in vitro means to evaluate cosmetic and pharmaceutical agents designed to modulate skin pigmentation. For more information on MelanoDerm, click here.


MelanoDerm tissue model histology image

For more information, view Technical References.