Tissue Models
16-Kauren-2-beta-18,19-triol inhibits melanosome transport in melanocytes by down-regulation of melanophilin expression
- TR Number: 1021
- Authors: Cheol Hwan Myung, Kyuri Kim, Jong Il Park, Ji Eun Lee, Jeong Ah Lee, Sung Chan Hong, Kyung-Min Lim, Jae Sung Hwang
- Materials Tested: 16-Kauren, plant-derived diterpenoid
- Link to PDF: https://pubmed.ncbi.nlm.nih.gov/31892452/
Rab27a, Mlph, and MyoVa form a tripartite complex and relate to melanosome distribution. Melanophilin (Mlph) acts as a linker protein between Rab27a and MyoVa. The biological activity and function of 16-kauren on the expression of Mlph has not yet been studied.
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