NON-ANIMAL METHODS FOR TOXICITY TESTING: EYE IRRITATION CORROSION.

• TR Number: 584

One component in the safety assessment of many types of products is the evaluation of their potential to cause eye injury. Eye irritation is defined as “the production of changes in the eye following the application of test substance to the anterior surface of the eye, which are fully reversible within 21 days of application” (UNECE, 2004). Eye corrosion [serious eye damage] is defined as “the production of tissue damage in the eye, or serious physical decay of vision, following application of a test substance to the anterior surface of the eye, which is not fully reversible within 21 days of application” (UNECE, 2004).