Tissue Models
Basket-weave structure in the stratum corneum is an important factor for maintaining the physiological properties of human skin as studied using reconstructed human epidermis and tape stripping of human cheek skin
- TR Number: 862
- Authors: H. Goto, A. Tada, A. Ibe and Y. Kitajima
- Materials Tested: oil-in-water emulsion, petroleum jelly, glycerin, butylene glycol, Cyclopentasiloxane, Quaternium-18 hectorite, polyethylene glycol-10 dimethicone, polyethylene glycol -2 stearate, stearic acid
The normal stratum corneum (SC) has an upper basket-weave (BW) pattern layer and a lower compact layer. The transition from compact to BW SC is well associated with a transition from diffuse to peripheral distributions of corneodesmosomes (CDs). The loss of transition from compact SC to BW SC appears to cause structural and barrier-function impairments.
Reference Application
- Pigmentation
- Transbuccal permeation/penetration
- Micronucleus Assay
- Skin aging
- Intestinal barrier
- Liver Toxicity
- Consumer products
- UV radiation
- Basic cutaneous research
- Epithelial restitution
- Microbial
- Pigmentation studies
- Oral mucosa
- microbiome
- Skin disease
- SARS-CoV-2
- Skin Toxicity
- Cytotoxicity
- Anti-aging
- Basic DC research
- Eye irritation
- Microbicide
- Radiation
- Tumor invasion
- Probiotic
- Intestinal infection
- Skin re-epithelization
- Crohn's Disease
- Inflammatory response
- Skin hydration
- UV
- Genetic toxicology
- Microbicide testing
- Reproducibility - eye (ocular) tissue model
- UV light
- Irritation>Eye Irritation OECD TG 492
- Skin differentiation
- Barrier repair
- Inflamed Bowel Disease
- Visible Light
- UV toxicity
- Basic respiratory research
- Genomics
- STD infection
- Reproducibility - skin tissue models
- UV protection
- Corneal Drug Delivery
- UV damage
- transporters
- Regulatory Approval
- Review Article
- Absorption
- Antimicrobial
- Buccal delivery
- Genotoxicity
- Mucosal delivery
- Nanotechnology
- Aging
- Respiratory Disease
- Bacterial infection
- Pollution
- Mildness Testing
- Barrier Disruption
- Drug delivery
- Infectious disease research
- Buccal drug delivery
- Pharmacotoxicology
- Nasal absorption
- Respiratory immunotoxicity
- Human-on-a-chip
- Atopic Dermatitis
- DNA Damage
- Colitis
- Drug ADME
- Hair Growth
- Irritation
- Infection
- Mucosal irritation
- Psoriasis
- Vaginal irritation
- Respiratory infection
- Viral Infection
- Melanogenesis
- Antiviral
- Gastrointestinal Disease
- Hazard assessment
- Biomedical Devices
- Permeation
- Infections
- Cosmetics
- Metabolism
- Mucous
- Respiratory toxicology
- MMPs
- Intestinal Permeation
- Bacterial colonization
- Translational toxicology
- Dry skin
- drug skin compatibility
- Skin irritation
- Toxicity
- Cytokine analysis
- Immulogical research
- Nanoparticle toxicology/penetration
- Skin cancer
- Photoaging
- Electrolyzed Water
- Transbuccal drug delivery
- XtraMild skin mildness testing
- Skin moisturization
- Protein Expression
- Allergenicity
- Antioxidants
- Drug absorption
- Immunologicaal research
- Toxicology
- Skin corrosion
- Skin Sensitization
- Fibrosis
- Oral Pathology
- bacterial vaginosis
- ADME
- Gastrointestinal Inflammation
- Immunological Research
- Apoptosis
- Intestinal toxicity
- Microbicides
- Nanotoxicology
- Penetration
- Medical Devices
- Pulmonary Fibrosis
- Oral infection
- vaginal microbiome
- Microphysiological system
- Gastrointestinal Irritation
- Immunogenicity
- Basic dermal research
- Respiratory research
- Immunotoxicity
- Ocular irritation
- Skin lightening
- Organ-on-a-Chip
- Oxidative Stress
- Oral inflammation
- Collagen Remodeling
- Hyperpigmentation
- Barrier Function
- Inflammation
- Asthma
- Skin corrosion Absorption
- Mucosal
- Oral candidiasis
- Skin
- Oral Disease Research
- Skin Damage
- Ocular toxicology
- Drug Screening
- Skin de-pigmentation
- Gastrointestinal Toxicity
- Microbial infection
- COPD
- Smoking
- Respiratory toxicity
- Oral irritation
- Smoker
- Space Research
- Skin Barrier
- Validation
- Nephrotoxicity
- Cancer Research
- Skin Brightening
- Wound healing
- Smoke
- Tobacco
- Inhalation Toxicology
- Oral mucositis
- Gingivitis
- Dry Eye
- Drug Metabolism
- Biofilm
- Hepatotoxicity
- Personalized Medicine
- Food Additives
- Phototoxicity
- Research
- Drug development
- Nanoparticles
- Skin pigmentation
Reference Product
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