Tissue Models
Targeting Multiple Hallmarks of Skin Aging: Preclinical and Clinical Efficacy of a Novel Growth Factor-Based Skin Care Serum
- TR Number: 1011
- Authors: Gail K. Naughton . Lily I. Jiang . Elizabeth T. Makino . Robin Chung . Audrey Nguyen . Tsing Cheng . Kuniko Kadoya . Rahul C. Mehta
- Materials Tested: UVB, skin care serum
- Link to PDF: https://pubmed.ncbi.nlm.nih.gov/36374431/
The aging process involves numerous biological mechanisms that have been characterized and proposed as the ‘‘hallmarks of aging.’’ Targeting the processes and pathways related to these hallmarks of aging that cause and promote skin aging could provide anti-aging benefits. A novel topical growth factor-based skin care serum (A+) was developed using human fibroblast conditioned media. This study aimed to assess the effects of A+ on four hallmarks of aging and its clinical efficacy in skin rejuvenation in subjects with moderate to severe overall facial photodamage.
Reference Application
- UV damage
- transporters
- Regulatory Approval
- Review Article
- Absorption
- Antimicrobial
- Buccal delivery
- Genotoxicity
- Mucosal delivery
- Reproducibility - skin tissue models
- UV protection
- Corneal Drug Delivery
- Bacterial infection
- Pollution
- Mildness Testing
- Barrier Disruption
- Drug delivery
- Infectious disease research
- Buccal drug delivery
- Pharmacotoxicology
- Nasal absorption
- Nanotechnology
- Aging
- Respiratory Disease
- DNA Damage
- Colitis
- Drug ADME
- Hair Growth
- Irritation
- Infection
- Mucosal irritation
- Psoriasis
- Vaginal irritation
- Respiratory immunotoxicity
- Human-on-a-chip
- Atopic Dermatitis
- Antiviral
- Gastrointestinal Disease
- Hazard assessment
- Biomedical Devices
- Permeation
- Infections
- Cosmetics
- Metabolism
- Mucous
- Respiratory infection
- Viral Infection
- Melanogenesis
- Bacterial colonization
- Translational toxicology
- Dry skin
- drug skin compatibility
- Skin irritation
- Toxicity
- Cytokine analysis
- Immulogical research
- Nanoparticle toxicology/penetration
- Respiratory toxicology
- MMPs
- Intestinal Permeation
- Transbuccal drug delivery
- XtraMild skin mildness testing
- Skin moisturization
- Protein Expression
- Allergenicity
- Antioxidants
- Drug absorption
- Immunologicaal research
- Toxicology
- Skin cancer
- Photoaging
- Electrolyzed Water
- Oral Pathology
- bacterial vaginosis
- ADME
- Gastrointestinal Inflammation
- Immunological Research
- Apoptosis
- Intestinal toxicity
- Microbicides
- Nanotoxicology
- Skin corrosion
- Skin Sensitization
- Fibrosis
- Oral infection
- vaginal microbiome
- Microphysiological system
- Gastrointestinal Irritation
- Immunogenicity
- Basic dermal research
- Respiratory research
- Immunotoxicity
- Ocular irritation
- Penetration
- Medical Devices
- Pulmonary Fibrosis
- Oral inflammation
- Collagen Remodeling
- Hyperpigmentation
- Barrier Function
- Inflammation
- Asthma
- Skin corrosion Absorption
- Mucosal
- Oral candidiasis
- Skin lightening
- Organ-on-a-Chip
- Oxidative Stress
- Ocular toxicology
- Drug Screening
- Skin de-pigmentation
- Gastrointestinal Toxicity
- Microbial infection
- COPD
- Smoking
- Respiratory toxicity
- Oral irritation
- Skin
- Oral Disease Research
- Skin Damage
- Validation
- Nephrotoxicity
- Cancer Research
- Skin Brightening
- Wound healing
- Smoke
- Tobacco
- Inhalation Toxicology
- Oral mucositis
- Smoker
- Space Research
- Skin Barrier
- Biofilm
- Hepatotoxicity
- Personalized Medicine
- Food Additives
- Phototoxicity
- Research
- Drug development
- Nanoparticles
- Skin pigmentation
- Gingivitis
- Dry Eye
- Drug Metabolism
- Intestinal barrier
- Liver Toxicity
- Consumer products
- UV radiation
- Basic cutaneous research
- Epithelial restitution
- Microbial
- Pigmentation
- Transbuccal permeation/penetration
- Micronucleus Assay
- Skin aging
- SARS-CoV-2
- Skin Toxicity
- Cytotoxicity
- Anti-aging
- Basic DC research
- Eye irritation
- Microbicide
- Pigmentation studies
- Oral mucosa
- microbiome
- Skin disease
- Skin re-epithelization
- Crohn's Disease
- Inflammatory response
- Skin hydration
- UV
- Genetic toxicology
- Microbicide testing
- Radiation
- Tumor invasion
- Probiotic
- Intestinal infection
- Barrier repair
- Inflamed Bowel Disease
- Visible Light
- UV toxicity
- Basic respiratory research
- Genomics
- STD infection
- Reproducibility - eye (ocular) tissue model
- UV light
- Irritation>Eye Irritation OECD TG 492
- Skin differentiation
Reference Product
Ready to advance your science?
Our team is ready to provide a cost-free consultation to determine how we can help you reach your research and testing goals. Contact our team of experts today.