Tissue Models
Production and characterization of a human antisperm monoclonal antibody against CD52g for topical contraception in women
- TR Number: 1017
- Authors: Gabriela Baldeon-Vaca, Jai G. Marathe, Joseph A. Politch, Emilie Mausser, Jeffrey Pudney James Doud, Ellena Nador, Larry Zeitlin, Michael Pauly, Thomas R. Moench, Miles Brennan, Kevin J. Whaley, Deborah J. Anderson
- Materials Tested: human sperm, anti-sperm monoclonal antibody, VRC01-N, anti-HIV IgG1 monoclonal antibody
- Link to PDF: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00271-1/fulltext
Approximately 40% of human pregnancies are unintended, indicating a need for more acceptable effective contraception methods. New antibody production systems make it possible to manufacture reagent-grade human monoclonal antibodies (mAbs) for clinical use. We used the Nicotiana platform to produce a human antisperm mAb and tested its efficacy for on-demand topical contraception.
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- Absorption
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- UV protection
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- Review Article
- Drug delivery
- Infectious disease research
- Buccal drug delivery
- Pharmacotoxicology
- Nasal absorption
- Nanotechnology
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- Bacterial infection
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- Respiratory immunotoxicity
- Human-on-a-chip
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- DNA Damage
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- Hair Growth
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- Infections
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- Respiratory infection
- Viral Infection
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- Skin irritation
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- MMPs
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- Translational toxicology
- Dry skin
- drug skin compatibility
- Allergenicity
- Antioxidants
- Drug absorption
- Immunologicaal research
- Toxicology
- Skin cancer
- Photoaging
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- Transbuccal drug delivery
- XtraMild skin mildness testing
- Skin moisturization
- Protein Expression
- Immunological Research
- Apoptosis
- Intestinal toxicity
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- bacterial vaginosis
- ADME
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- Immunogenicity
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- Penetration
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- Oral infection
- vaginal microbiome
- Microphysiological system
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- Oral candidiasis
- Skin lightening
- Organ-on-a-Chip
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- Oral inflammation
- Collagen Remodeling
- Hyperpigmentation
- Barrier Function
- Microbial infection
- COPD
- Smoking
- Respiratory toxicity
- Oral irritation
- Skin
- Oral Disease Research
- Skin Damage
- Ocular toxicology
- Drug Screening
- Skin de-pigmentation
- Gastrointestinal Toxicity
- Wound healing
- Smoke
- Tobacco
- Inhalation Toxicology
- Oral mucositis
- Smoker
- Space Research
- Skin Barrier
- Validation
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- Cancer Research
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- Research
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- Microbial
- Pigmentation
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- Micronucleus Assay
- Skin aging
- Intestinal barrier
- Liver Toxicity
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- Anti-aging
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- Eye irritation
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- Oral mucosa
- microbiome
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- SARS-CoV-2
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- Skin hydration
- UV
- Genetic toxicology
- Microbicide testing
- Radiation
- Tumor invasion
- Probiotic
- Intestinal infection
- Skin re-epithelization
- Crohn's Disease
- Inflammatory response
- UV toxicity
- Basic respiratory research
- Genomics
- STD infection
- Reproducibility - eye (ocular) tissue model
- UV light
- Irritation>Eye Irritation OECD TG 492
- Skin differentiation
- Barrier repair
- Inflamed Bowel Disease
- Visible Light
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