Tissue Models
Production and characterization of a human antisperm monoclonal antibody against CD52g for topical contraception in women
- TR Number: 1017
- Authors: Gabriela Baldeon-Vaca, Jai G. Marathe, Joseph A. Politch, Emilie Mausser, Jeffrey Pudney James Doud, Ellena Nador, Larry Zeitlin, Michael Pauly, Thomas R. Moench, Miles Brennan, Kevin J. Whaley, Deborah J. Anderson
- Materials Tested: human sperm, anti-sperm monoclonal antibody, VRC01-N, anti-HIV IgG1 monoclonal antibody
- Link to PDF: https://www.thelancet.com/journals/ebiom/article/PIIS2352-3964(21)00271-1/fulltext
Approximately 40% of human pregnancies are unintended, indicating a need for more acceptable effective contraception methods. New antibody production systems make it possible to manufacture reagent-grade human monoclonal antibodies (mAbs) for clinical use. We used the Nicotiana platform to produce a human antisperm mAb and tested its efficacy for on-demand topical contraception.
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