Tissue Models
DOPAMINE TRANSPORT ACROSS RESPIRATORY EPITHELIUM.
- TR Number: 314
- Authors: Chemuturi1, N., Donovan1, M., Klausner2, M., and Hayden2, P. 1College of Pharmacy, University of Iowa, Iowa City, IA. 2Mattek Corporation, Ashland, MA.
- Materials Tested: Amantadine HC1, Dopamine HC1, GBR 12935, Nomifensive maleate
Dopamine is a catecholamine neurotransmitter implicated in CNS related disorders such as Parkinson’s disease, schizophrenia and Huntington’s disease. It is known to be transported by the dopamine transporter (DAT) in the CNS and an organic cation transporter (OCT) peripherally. It is orally ineffective due to high first pass metabolism and its inability to cross the blood brain barrier. Intranasal dopamine administration has shown preferential uptake into the brain as compared to intravenous administration. Bovine respiratory explants and a novel human derived tracheo/bronchial tissue system were used to investigate the processes underlying dopamine transport.
Reference Application
- Skin irritation
- Toxicity
- Cytokine analysis
- Immulogical research
- Nanoparticle toxicology/penetration
- Respiratory toxicology
- MMPs
- Intestinal Permeation
- Bacterial colonization
- Translational toxicology
- Dry skin
- drug skin compatibility
- Allergenicity
- Antioxidants
- Drug absorption
- Immunologicaal research
- Toxicology
- Skin cancer
- Photoaging
- Electrolyzed Water
- Transbuccal drug delivery
- XtraMild skin mildness testing
- Skin moisturization
- Protein Expression
- Immunological Research
- Apoptosis
- Intestinal toxicity
- Microbicides
- Nanotoxicology
- Skin corrosion
- Skin Sensitization
- Fibrosis
- Oral Pathology
- bacterial vaginosis
- ADME
- Gastrointestinal Inflammation
- Immunogenicity
- Basic dermal research
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- Ocular irritation
- Penetration
- Medical Devices
- Pulmonary Fibrosis
- Oral infection
- vaginal microbiome
- Microphysiological system
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- Asthma
- Skin corrosion Absorption
- Mucosal
- Oral candidiasis
- Skin lightening
- Organ-on-a-Chip
- Oxidative Stress
- Oral inflammation
- Collagen Remodeling
- Hyperpigmentation
- Barrier Function
- Microbial infection
- COPD
- Smoking
- Respiratory toxicity
- Oral irritation
- Skin
- Oral Disease Research
- Skin Damage
- Ocular toxicology
- Drug Screening
- Skin de-pigmentation
- Gastrointestinal Toxicity
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- Smoke
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- UV radiation
- Basic cutaneous research
- Epithelial restitution
- Microbial
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- Micronucleus Assay
- Skin aging
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- Liver Toxicity
- Consumer products
- Anti-aging
- Basic DC research
- Eye irritation
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- Pigmentation studies
- Oral mucosa
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- SARS-CoV-2
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- UV
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- Radiation
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- Intestinal infection
- Skin re-epithelization
- Crohn's Disease
- Inflammatory response
- UV toxicity
- Basic respiratory research
- Genomics
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- Reproducibility - eye (ocular) tissue model
- UV light
- Irritation>Eye Irritation OECD TG 492
- Skin differentiation
- Barrier repair
- Inflamed Bowel Disease
- Visible Light
- Absorption
- Antimicrobial
- Buccal delivery
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- Reproducibility - skin tissue models
- UV protection
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- Psoriasis
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- Respiratory immunotoxicity
- Human-on-a-chip
- Atopic Dermatitis
- DNA Damage
- Colitis
- Drug ADME
- Hair Growth
- Permeation
- Infections
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- Mucous
- Respiratory infection
- Viral Infection
- Melanogenesis
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- Hazard assessment
- Biomedical Devices
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