ASSESSMENT OF HUMAN CADAVER AND RECONSTRUCTED SKIN MODELS TO PREDICT PHARMACOKINETICS OF TESTOSTERONE TRANSDERMAL DRUG DELIVERY PATCHES.0
Testosterone TDD patches were compared for in-vitro skin permeation characteristics and in the clinic for in-vivo pharmacokinetic parameters. In-vitro evaluations were conducted using both human cadaver and reconstructed skin models in order to determine a model predictive of in-vivo delivery. HCS was chosen at the model most predictive of testosterone in-vivo delivery. The preliminary IVIVC using HCS is very strong (r=0.99971).
Dermal absorption, Dermal penetration, Dermal permeation, EpiDerm, Equilvalents, Human skin, Percutaneous absorption, Percutaneous penetration, Permeation, Pre-validation, Prevalidation, Reconstructed human skin, TDD, Testosterone, Testosterone TDD patches, Transdermal, Transdermal drug delivery, Validation
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