Novel Organotypic Patient-Derived Primary Tumor Tissues for Oncology Drug Safety and Efficacy Studies

Organotypic, three-dimensional (3D) cancer tissue models (OCTM) have enabled investigators to develop predictive markers that can be used in preclinical cancer drug development. However, a drawback of the existing models is that they are mostly cell line-based are not physiologic. In vitro development of 3D tumoroids using patient derived primary tumors (PDPT) in tumor microenvironment […]

Carbamazepine Inhibition Of N-Methyl-D-Aspartate-Evoked Calcium Influx In Rat Cerebellar Granule Cells

Mitochondrial Production Of Reactive Oxygen Species In Cortical Neurons Following Exposure To N-Methyl-D-Aspartate

Steroid Potentiation And Inhibition Of N-Methyl-D-Aspartate Receptor-Mediated Intracellular Ca++ Responses: Structure-Activity Studies

N-Methyl-D-Aspartate Induces A Rapid; Reversible; And Calcium-Dependent Intracellular Acidosis In Cultured Fetal Rat Hippocampal Neurons

Ionic Currents And Electromotility In Inner Ear Hair Cells From Humans

Laminin-Like Proteins Are Differentially Regulated During Cerebellar Development And Stimulate Granule Cell Neurite Outgrowth In Vitro.

Heterotrimeric G Protein Activation Rapidly Inhibits Outgrowth Of Optic Axons From Adult And Embryonic Mouse; And Gold Fish Retinal Explants.

Heat-Resistant Factors In Human Erythrocyte Membranes Mediate Cd4-Dependent Fusion With Cells Expressing Hiv-1 Envelope Glycoproteins.

Overexpression Of Cofilin Stimulates Bundling Of Actin Filaments; Membrane Ruffling; And Cell Movement In Dictyostelium

Ampa Receptor Activation Is Rapidly Toxic To Cortical Astrocytes When Desensitization Is Blocked.

Microinjection Of Fluorescently Labeled alpha -Actinin Into Living Cells

Metabolic Impairment Elicits Brain Cell Type-Selective Changes In Oxidative Stress And Cell Death In Culture

Metabolic Impairment Induces Oxidative Stress; Compromises Inflammatory Responses; And Inactivates A Key Mitochondrial Enzyme In Microglia

Effects of 42 deg. C hyperthermia on intracellular pH in ovarian carcinoma cells during acute or chronic exposure to low extracellular pH

An Essential Role For Autophosphorylation In The Dissociation Of Activated Protein Kinase C From The Plasma Membrane

Visualization Of Dynamic Trafficking Of A Protein Kinase C B Ii/Green Fluorescent Protein Conjugate Reveals Differences In G Protein-Couples Receptor Activation And Desensitization

Cellular Trafficking Of G Protein-Coupled Receptor/?-Arrestin Endocytic Complexes.

Adenovirus-Mediated Knockout Of A Conditional Glucokinase Gene In Isolated Pancreatic Islets Reveals An Essential Role For Proximal Metabolic Coupling Events In Glucose-Stimulated Insulin Secretion

Trafficking Of Endothelial Nitric-Oxide Synthase In Living Cells

Quantitative Subcellular Imaging Of Glucose Metabolism Within Intact Pancreatic Islets

Nuclear Trafficking Of Photoreceptor Protein Crx: The Targeting Sequence And Pathological Implications

Continuous Measurement Of Changes In Intracellular Calcium Concentration In Mouse Splenic T Cells Attached To A Glass Substrate

Shc And Fak Differentially Regulate Cell Motility And Directionality Modulated By Pten

Fluorescence-Imaged Microdeformation Of The Outer Hair Cell Lateral Wall

Calpain Activation Contributes To Dendritic Remodeling After Brief Excitotoxic Injury In Vitro

Nerve Growth Factor Modulates Synaptic Transmission Between Sympathetic Neurons And Cardiac Myocytes

Quantitative Imaging Of Green Fluorescent Protein In Cultured Cells: Comparison Of Microscopic Techniques; Use In Fusion Proteins And Detection Limits

Mapping Sites Where Replication Initiates In Mammalian Cell Using DNA fibers

Quantitative Imaging Of Tata-Binding Protein In Living Yeast Cells

Sites Of Monomeric Actin Incorporation In Living Ptk2 And Ref-52 Cells.

Analysis Of Cell Mechanics In Single Vinculin-Deficient Cells Using A Magnetic Tweezer.

Cross-Linking Of Cell Surface Receptors Enhances Cooperativity Of Molecular Adhesion

COPI-Coated ER-To-Golgi Transport Complexes Segregate From Copii In Close Proximity To ER Exit Sites

The Multidrug-Resistant Phenotype Associated With Overexpression Of The New Abc Half-Transporter; Mxr (Abcg2).

Transverse And Lateral Mobility In Outer Hair Cell Lateral Wall Membranes

Video-Rate Scanning Two-Photon Excitation Fluorescence Microscopy And Ratio Imaging With Cameleons.

Distinct Membrane Domains On Endosomes In The Recycling Pathway Visualized By Multicolor Imaging Of Rab4; Rab5 And Rab11

Probing Intracellular Dynamics In Living Cells With Near-Field Optics

A Human Cell System For Detecting Asbestos Cytogenotoxicity In Vitro.

The Role Of Local Actin Instability In Axon Formation

Mucosal Mast Cell Secretion Processes Imaged Using Three-Photon Microscopy Of 5-Hydroxytryptamine Autofluorescence

Regulation Of Receptor-Mediated Protein Kinase C Membrane Trafficking By Autophosphorylation

Molecular Dynamics In Living Cells Observed By Fluorescence Correlation Spectroscopy With One- And Two-Photon Excitation

Immunolocalization Of The Cocaine- And Antidepressant-Sensitive 1-Norepinephrine Transporter

Paka; A Putative Pak Family Member; Is Required For Cytokinesis And The Regulation Of The Cytoskeleton In Dictyostelium Discoideum Cells During Chemotaxis

Meso-2;3-Dimercaptosuccinic Acid Induces Calcium Transients In Cultured Rhesus Monkey Kidney Cells

Intracellular Ca²+ Concentrations In Cultured Chicken Photoreceptor Cells: Sustained Elevation In Depolarized Cells And The Role Of Dihydropyridine-Sensitive Ca²+ Channels

Histone-Gfp Fusion Protein Enables Sensitive Analysis Of Chromosome Dynamics In Living Mammalian Cells

A Novel Casein Kinase 2 A-Subunit Regulates Membrane Protein Traffic In The Human Hepatoma Cell Line Huh-7

Beta1-Adrenergic Receptor Association with PSD-95

Capacitative Calcium Entry Deficits And Elevated Luminal Calcium Content In Mutant Presenilin-1 Knockin Mice

Differential Alterations In Antioxidant Capacity In Cells From Alzheimer Patients

The Sonic Hedgehog Receptor Patched Associates With Caveolin-1 In Cholesterol-Rich Microdomains Of The Plasma Membrane

Argosomes: A Potential Vehicle For The Spread Of Morphogens Through Epithelia

Cell Type-Specific Differences In Glycosaminoglycans Modulate The Biological Activity Of A Heparin-Binding Peptide (Rkrlqvqlsirt) From The G Domain Of The Laminin ?1 Chain

The C2A Domain Of Double C2 Protein ? Contains A Functional Nuclear Localization Signal

The Subnuclear Three-Dimensional Image Analysis Of Androgen Receptor Fused To Green Fluorescence Protein

Early Intermediates In Hiv-1 Envelope Glycoprotein-Mediated Fusion Triggered By Cd4 And Co-Receptor Complexes

Unreliability Of The Cytochrome C-Enhanced Green Fluorescent Fusion Protein As A Marker Of Cytochrome C Release In Cells That Overexpress Bcl-2

Endocytosis Is Enhanced In Tangier Fibroblasts. Possible Role Of Atp-Binding Cassette Protein A1 In Endosomal Vesicular Transport

Transient expression Of Wild-Type Or Mitochondrially Targeted Bcl-2 Induces Apoptosis; Whereas Transient expression Of Endoplasmic Reticulum-Targeted Bcl-2 Is Protective Against Bax-Induced Cell Death

Formation Of Crystalloid Endoplasmic Reticulum Induced By Expression Of Synaptotagmin Lacking The Conserved Whxl Motif In The C Terminus

Photodynamic Therapy-Induced Apoptosis In Epidermoid Carcinoma Cells. Reactive Oxygen Species And Mitochondrial Inner Membrane Permeabilization.

Caveolin-1 Inhibits Epidermal Growth Factor-Stimulated Lamellipod Extension And Cell Migration In Metastatic Mammary Adenocarcinoma Cells (Mtln3)

Rab5 Association With The Angiotensin Ii Type 1A Receptor Promotes Rab5 Gtp Binding And Vesicular Fusion

Lead Inhibits Meso-2;3-Dimercaptosuccinic Acid Induced Calcium Transients In Cultured Rhesus Monkey Kidney Cells

Calcium Is A Key Signaling Molecule In ß-Lapachone-Mediated Cell Death

Role Of The Conserved Whxl Motif In The C Terminus Of Synaptotagmin In Synaptic Vesicle Docking

Protein And Lipids Define The Diffusional Field Of Nitric Oxide

The Actin-Binding Protein Hip1R Associates With Clathrin During Early Stages Of Endocytosis And Promotes Clathrin Assembly In Vitro

Translocation Of Rna Granules In Living Neurons

Stable Expression Of Protective Protein/ Cathepsin A-Green Fluorescent Protein Fusion Genes In A Fibroblastic Cell Line From A Galactosialidosis Patient. Model System For Revealing The Intracellular Transport Of Normal And Mutated Lysosomal Enzymes

MARCKS Regulates Membrane Ruffling And Cell Spreading

Differentiated Neurons Retain The Capacity To Generate Axons From Dentrites

Tyrosine Phosphorylation Regulates The Expression Of Major Histo-Compatibility Complex Antigens On A Human Lung Cancer Cell Line By Interferon-Gamma

Effects Of Extracellular Acidification On Intracellular Ph And Atp-Induced Calcium Mobilization In Rabbit Lens Epithelial Cells

Epidermal Growth Factor Receptor Distribution During Chemotactic Responses.

Fluorescent Stereo Microscope Reporter Of Cre Recombinase Expression In Living Cells.

Tyrosine Phosphorylation Of Paxillin ? Is Involved In Temporospatial Regulation Of Paxillin-Containing Focal Adhesion Formation And F-Actin Organization In Motile Cells

Functional Importance Of The Ala116-Pro136 Region In The Calcium-Sensing Receptor

GABA Expression Dominates Neuronal Lineage Progression in the Embryonic Rat Neocortex and Facilitates Neurite Outgrowth via GABAa Autoreceptor/Cl- Channels

The C-Terminal Polylysine Region And Methylation Of K-Ras Are Critical For The Interaction Between K-Ras And Microtubules

Brief Treatments with Forskolin Enhance S-Phase Entry in Balance Epithelia from the Ears of Rats

Rh Type B Glycoprotein Is A New Member Of The Rh Superfamily And A Putative Ammonia Transporter In Mammals

Ampa Exposures Induce Mitochondrial Ca2+ Overload And Ros Generation In Spinal Motor Neurons In Vitro

Visualization of a Functional Gαq-Green Fluorescent Protein Fusion in Living Cells

The Supporting-Cell Antigen: A Receptor-Like Protein Tyrosine Phosphatase Expressed In The Sensory Epithelia Of The Avian Inner Ear

Ligand-Induced Dynamic Membrane Changes And Cell Deletion Conferred By Vanilloid Receptor 1

Tenascin-R Inhibits The Growth Of Optic Fibers In Vitro But Is Rapidly Eliminated During Nerve Regeneration In The Salamander Pleurodeles Waltl

Generation Of Neuronal Intranuclear Inclusions By Polyglutamine-Gfp: Analysis Of Inclusion Clearance And Toxicity As A Function Of Polyglutamine Length

Membrane Tether Formation from Outer Hair Cells with Optical Tweezers

Slow intercellular Ca2+ signaling in wild-type and Cx43-null neonatal mouse cardiac myocytes

Urea signaling to ERK phosphorylation in renal medullary cells requires extracellular calcium but not calcium entry

Abundant GFP Expression and LTP in Hippocampal Acute Slices by In Vivo Injection of Sindbis Virus

Surface-expressed Lamellar Body Membrane is Recycled to Lamellar Bodies

Intercellular Calcium Waves in HeLa Cells Expressing GFP-labeled Connexin 43; 32; or 26

Effects Of Human Antithymocyte Globulin On Acetylcholine Synthesis; Its Release And Choline Acetyltransferase Transcription In A Human Leukemic T-Cell Line

Phosphorylation-dependent Localization of Microtubule-associated Protein MAP2c to the Actin Cytoskeleton

Sustained Ca2+-Induced Ca2+-Release Underlies The Post-Glutamate Lethal Ca2+ Plateau In Older Cultured Hippocampal Neurons