FURTHER DEVELOPMENT OF A MICRONUCLEUS ASSAY USING THE HUMAN 3-D SKIN MODEL, EPIDERM™.

Curren1, R.D., Aardema², M.J., Hayden³, P.J., Mun1, G., Hu², T. 1Institute for In Vitro Sciences, Gaithersburg, MD, ²Procter & Gamble, Cincinnati, OH, ³MatTek Corporation, Ashland, MA.

Keywords

7th Amendment to the Cosmetics Directive, Binucleate Cells, Cosmetic Directive, Cosmetics, Cytochalasin B, EU 7th Amendment, Epiderm, Genotoxicity, Genotoxicity tests, Histology, In vitro, In vivo, Metabolism, Micronucleus, Micronucleus assay, Photogenetox, REACH, REACH program, RT-PCR, Stratum granulosum, Vinblastine sulfate (VB), Xenobiotic metabolizing activity

Materials Tested

1,2 Epoxydodecane, 2-ethyl-1,3-hexanediol, 4-Nitrophenol, BP, CP, DMBA, MMC, MMS, MNNG, Trichloroethylene, VB

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