Tissue Models
Replication Efficiency of Contemporary Highly Pathogenic Avian Influenza A(H5N1) Virus Isolates in Human Nasal Epithelium Model
- TR Number: 1114
- Authors: Meaghan Flagg, Christopher J Winski, Bridget G Brackney, Tessa R Lutterman, Johan A Ortiz-Morales, Brandi N Williamson, Emmie de Wit
- Keywords: EpiNasal, NAS-100, influenza A virus, avian influenza A H5N1, virus replication, interferon-stimulated genes, interferon-stimulated gene 15, interferon-induced transmembrane protein 3, myxovirus resistance 1, interleukin 6, tumor necrosis factor α, interleukin 1β, IL-6, TNF-a, IL-1b
- Materials Tested: avian influenza A H5N1
- Link to Article: https://pubmed.ncbi.nlm.nih.gov/42116615/
Abstract
Replication of influenza A virus in human nasal epithelium affects transmissibility and disease. We compared virus replication and immune responses in human nasal epithelium infected with seasonal and highly pathogenic avian influenza A(H5N1) viruses. Contemporary H5N1 viruses replicated better than the historical isolate; however, interferon response to B3.13 genotype viruses was dampened.
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