Tissue Models
RECONSTRUCTED HUMAN EPIDERMIS EQUIVALENTS.
- TR Number: 275
- Authors: Roguet1, R., Bracher2, M., Diembeck3, W., Ponec4, M. 1L'Oreal, Life Sciences, Advanced Research Laboratories, Clichy, France, 2Cosmital SA (Research Company of Wella AG, Germany), Marly, Switzerland. 3Beiersdorf AG, Hamburg, Germany, 4Humboldt University, Berlin, Germany. 4Department of Dermatology, University Hospital, Leiden, The Netherlands.
- Keywords: Benzoic acid, Caffeine, Cutaneous irritancy, Cutaneous irritation, Cutaneous toxicity, Detoxification, Dynamic diffusion cell, EpiDerm, EpiSkin, Human skin models, In vitro testing, Keratinocyte, Lauric acid, Mannitol, Percutaneous absorption, Permeation, Pharmacotoxicology, Quinone reductase, Reconstructed epidermis, Reconstructed human epidermis, Reconstructed human epidermis (RhE), Reconstructed skin, Reproducibility, RhE, Skin absorption, Skin irritancy, Skin irritation, Vehicle effects, Xenobiotics
Special Section. (See MatTek TR’s 276 thru 283.)
Reference Application
- Transbuccal permeation/penetration
- Micronucleus Assay
- Skin aging
- Intestinal barrier
- Liver Toxicity
- Consumer products
- Biocompatibility
- Personal Care
- UV radiation
- Basic cutaneous research
- Epithelial restitution
- Microbial
- Pigmentation
- Oral mucosa
- microbiome
- Skin disease
- SARS-CoV-2
- Skin Toxicity
- Cytotoxicity
- reproducibility
- GI Toxicity
- Anti-aging
- Basic DC research
- Eye irritation
- Microbicide
- Pigmentation studies
- Tumor invasion
- Probiotic
- Intestinal infection
- Skin re-epithelization
- Crohn's Disease
- Inflammatory response
- respiratory irritation
- Skin Allergenicity
- Skin hydration
- UV
- Genetic toxicology
- Microbicide testing
- Radiation
- UV light
- Irritation>Eye Irritation OECD TG 492
- Skin differentiation
- Barrier repair
- Inflamed Bowel Disease
- Visible Light
- pesticides
- desquamation
- UV toxicity
- Basic respiratory research
- Genomics
- STD infection
- Reproducibility - eye (ocular) tissue model
- UV protection
- Corneal Drug Delivery
- UV damage
- transporters
- Regulatory Approval
- Review Article
- LOAEL
- oral cancer treatment
- Absorption
- Antimicrobial
- Buccal delivery
- Genotoxicity
- Mucosal delivery
- Reproducibility - skin tissue models
- Aging
- Respiratory Disease
- Bacterial infection
- Pollution
- Mildness Testing
- Barrier Disruption
- UVB
- Drug delivery
- Infectious disease research
- Buccal drug delivery
- Pharmacotoxicology
- Nasal absorption
- Nanotechnology
- Human-on-a-chip
- Atopic Dermatitis
- DNA Damage
- Colitis
- Drug ADME
- Hair Growth
- scalp health
- Irritation
- Infection
- Mucosal irritation
- Psoriasis
- Vaginal irritation
- Respiratory immunotoxicity
- Viral Infection
- Melanogenesis
- Antiviral
- Gastrointestinal Disease
- Hazard assessment
- Biomedical Devices
- artificial saliva
- Permeation
- Infections
- Cosmetics
- Metabolism
- Mucous
- Respiratory infection
- MMPs
- Intestinal Permeation
- Bacterial colonization
- Translational toxicology
- Dry skin
- drug skin compatibility
- bacterial adherence
- Skin irritation
- Toxicity
- Cytokine analysis
- Immulogical research
- Nanoparticle toxicology/penetration
- Respiratory toxicology
- Photoaging
- Electrolyzed Water
- Transbuccal drug delivery
- XtraMild skin mildness testing
- Skin moisturization
- Protein Expression
- PBPK Modeling
- Allergenicity
- Antioxidants
- Drug absorption
- Immunologicaal research
- Toxicology
- Skin cancer
- Skin Sensitization
- Fibrosis
- Oral Pathology
- bacterial vaginosis
- ADME
- Gastrointestinal Inflammation
- anti-wrinkling
- Immunological Research
- Apoptosis
- Intestinal toxicity
- Microbicides
- Nanotoxicology
- Skin corrosion
- Medical Devices
- Pulmonary Fibrosis
- Oral infection
- vaginal microbiome
- Microphysiological system
- Gastrointestinal Irritation
- Nicotine pouch products
- Immunogenicity
- Basic dermal research
- Respiratory research
- Immunotoxicity
- Ocular irritation
- Penetration
- Organ-on-a-Chip
- Oxidative Stress
- Oral inflammation
- Collagen Remodeling
- Hyperpigmentation
- Barrier Function
- intranasal drug delivery
- Inflammation
- Asthma
- Skin corrosion Absorption
- Mucosal
- Oral candidiasis
- Skin lightening
- Oral Disease Research
- Skin Damage
- Ocular toxicology
- Drug Screening
- Skin de-pigmentation
- Gastrointestinal Toxicity
- permeation enhancement
- Microbial infection
- COPD
- Smoking
- Respiratory toxicity
- Oral irritation
- Skin
- Space Research
- Skin Barrier
- Validation
- Nephrotoxicity
- Cancer Research
- Skin Brightening
- excipients
- Wound healing
- Smoke
- Tobacco
- Inhalation Toxicology
- Oral mucositis
- Smoker
- Dry Eye
- Drug Metabolism
- Biofilm
- Hepatotoxicity
- Personalized Medicine
- Food Additives
- Sub-categorization
- Phototoxicity
- Research
- Drug development
- Nanoparticles
- Skin pigmentation
- Gingivitis
Reference Product
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