Nanoparticles

Particulate Matter Decreases Intestinal Barrier-Associated Proteins Levels in 3D Human Intestinal Model

Background: The gastrointestinal tract (GI) tract is one of the main organs exposed to particulate matter (PM) directly through ingestion of contaminated food or indirectly through inhalation. Previous studies have […]

Dicationic Amino Substituted Gemini Surfactants and their Nanoplexes: Improved Synthesis and Characterization of Transfection Efficiency and Corneal Penetration In Vitro

Purpose- To formulate and characterize nanoparticles from m-7NH-m gemini surfactants, synthesized by a new improved method, for non-invasive gene delivery including optimization of composition for transfection efficiency and corneal penetration. […]

Evaluation of Phototoxic and Cytotoxic Potential of TiO2 Nanosheets in a 3D Reconstructed Human Skin Model

Despite a continuous increase in commercial products containing nanoparticles, only few materials are currently used in such large amounts, forms and sizes as titanium dioxide – TiO2. Besides their use […]

Repeated long-term exposures of multi-walled carbon nanotubes to the 3D human lung model EpiAlveolar to predict the onset of fibrosis

Multi-walled carbon nanotubes (MWCNTs) with their extraordinary properties (e.g. stiffness, electrical conductivity, etc.) are among the most commonly used nanomaterials [1]. Human exposure to MWCNTs can occur throughout their life-cycle […]

Behaviour of Silver Nanoparticles in Simulated Saliva and Gastrointestinal Fluids

Continuously increasing application of silver nanoparticles (AgNPs) requires information on their safety and performance under biological conditions. Assessment of AgNPs in biological systems is also related to availability of robust […]

Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay

Background: Assessment of eye irritation hazard has long been a core requirement in any chemical legislation. Nevertheless, publications focusing on the eye damaging potential of nanomaterials are scarce. Traditionally, eye irritation testing […]

3D-WOUND HEALING MODEL: INFLUENCE OF MORPHINE AND SOLID LIPID NANOPARTICLES.

For efficient pain reduction in severe skin wounds, topically applied opioids may be a new option. Moreover, by stimulating keratinocyte migration opioids may also accelerate wound healing. Yet, conventional formulations […]

ASSESSMENT OF PHOTOTOXICITY, SKIN IRRITATION, AND SENSITIZATION POTENTIAL OF POLYSTYRENE AND TiO2 NANOPARTICLES.

The human skin equivalent model (HSEM) is well known as an attractive alternative model for evaluation of dermal toxicity. However, only limited data are available on the usefulness of an […]

THE STATE OF NANO-SIZED TITANIUM DIOXIDE (TIO2) MAY AFFECT SUNSCREEN PERFORMANCE.

In the past several years, there has been a trend in the sunscreen/cosmetics industry to replace micron-sized titanium dioxide (TiO2) particles with nanoscale materials. The increased use of nanoscale TiO2 […]

ASSESSMENT OF PENETRATION OF QUANTUM DOTS THROUGH IN VITRO AND IN VIVO HUMAN SKIN USING THE HUMAN SKIN EQUIVALENT MODEL AND THE TAPE STRIPPING METHOD.

Quantum dots (QDs) are rapidly emerging as an important class of nanoparticles (NPs) with potential applications in medicine. However, little is known about penetration of QDs through human skin. This […]

PARTICLE SIZE AND BILAYER RIGIDITY EFFECTS ON SKIN DIFFUSION OF NANOSOMES.

Preclinical development and ocular biodistribution of gemini-DNA nanoparticles after intravitreal and topical administration: Towards non-invasive glaucoma gene therapy

Gene therapy could offer improvement in the treatment of glaucoma compared to the current standard of lowering intraocular pressure. We have developed and characterized non-viral gemini surfactant-phospholipid nanoparticles (GL-NPs) for […]

ASSESSMENT OF DERMAL TOXICITY OF NANOSILICA USING CULTURED KERATINOCYTES, A HUMAN SKIN EQUIVALENT MODEL AND AN IN VIVO MODEL.

This study by researchers at Korea University College of Medicine and the National Institute of Toxicological Research (Korea) demonstrated how Mattek’s EpiDerm in vitro 3-D human skin tissue equivalent can […]

OXIDATIVE STRESS AND INFLAMMATORY RESPONSE IN DERMAL TOXICITY OF SINGLE-WALLED CARBON NANOTUBES.

This study by researchers at PPRB/NIOSH, West Virginia University and the University of Pittsburgh demonstrated that Mattek’s EpiDermFT full-thickness in vitro 3-D human skin tissue equivalent can be used to […]

ENHANCED ANTIVIRAL ACTIVITY OF ACYCLOVIR LOADED INTO NANOPARTICLES.

The activity of antivirals can be enhanced by their incorporation in nanoparticulate delivery systems. Peculiar polymeric nanoparticles, based on a β-cyclodextrin-poly (4-acryloylmorpholine) monoconjugate (β-CD-PACM), are proposed as acyclovir carriers. The […]