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microbiome

1033

Human 3D Colon Tissue Model for Toxicity and Microbiome studies

The human colon plays host to a wide variety of microbes living together in an ecosystem. Any damage or injury to the colonic epithelium disturbs this ecosystem which can in turn lead to inflammation and disease. The colonic epithelium is a dynamic structure with a self-renewing capacity and serves as an organ for reabsorption of […]
969

A Novel Macrophage Containing Organotypic Small Intestinal Tissue for Modeling Gut Inflammation

As gatekeepers of intestinal immunehomeostasis, macrophages play a critical role in inflammation in the gut. In this study, were constructed a new macrophage-containing primary cell-based full-thickness small intestinal(SMI+M) tissue model and characterized it for:1) macrophage incorporation (immunohistochemistry, IHC), 2) barrier properties(TEER), and 3)functionality by measuring inflammatory responses following exposure to ligands for TLR4 (lipopolysaccharide;LPS),NOD1(C12-iE-DAP)andNOD2(L18-MDP) either […]
961

Spermidine-induced recovery of human dermal structure and barrier function by skin microbiome

An unbalanced microbial ecosystem on the human skin is closely related to skin diseases and has been associated with inflammation and immune responses. However, little is known about the role of the skin microbiome on skin aging. Here, we report that the Streptococcus species improved the skin structure and barrier function, thereby contributing to anti-aging. […]
950

Novel Vaginal Microflora Colonization Model Providing New Insight into Microbicide Mechanism of Action

Several broad-spectrum microbicides, including cellulose sulfate (CS), have passed conventional preclinical and phase I clinical safety evaluation and yet have failed to protect women from acquiring IDV -1 in phase II/Ill trials. Concerns have been raised that current preclinical algorithms are deficient in addressing the complexity of the microflora-regulated vaginal mucosal barrier. We applied a […]
933

A mixed community of skin microbiome representatives influences cutaneous processes more than individual members

Skin, the largest organ of the human body by weight, hosts a diversity of microorganisms that can influence health. The microbial residents of the skin are now appreciated for their roles in host immune interactions, wound healing, colonization resistance, and various skin disorders. Still, much remains to be discovered in terms of the host pathways […]
917

Microbially competent 3D skin: a test system that reveals insight into host–microbe interactions and their potential toxicological impact

The skin`s microbiome is predominantly commensalic, harboring a metabolic potential far exceeding that of its host. While there is clear evidence that bacteria-dependent metabolism of pollutants modulates the toxicity for the host there is still a lack of models for investigating causality of microbiome-associated pathophysiology or toxicity. We now report on a biologically characterized microbial–skin […]
820

Layer-by-Layer Encapsulation of Probiotics for Delivery to the Microbiome

Recent discoveries in biology and microbiology have highlighted the importance of the gastrointestinal (GI) microbiome in regulating human health and disease. Thus, the delivery of probiotics to influence and modulate microbiome compositions can potentially impact the treatment of a number of human diseases. Unfortunately, biological challenges encountered during oral delivery have limited the translation of many probiotic-delivering technologies. Here, we report […]