TESTING AND IMPROVEMENT OF RECONSTRUCTED SKIN KITS IN ORDER TO ELABORATE EUROPEAN STANDARDS: FIRST RESULTS.

• TR Number: 179
• Authors: Roguet, R., Beck1, H., Boelsma2, E., Bracher1, M., Faller1, C., Harris2, I., Lotte, C., Dreher, F., Ponec2, M. L'Oréal, Life Sciences Research, 92583 Clichy, France, 1Department of In Vitro Toxicology, WELLA/COSMITAL, Marly, France, 2Department of Dermatology, University Hospital, Leiden, The Netherlands, 3Department of Molecular Biology, Beiersdorf AG, Hamburg, Germany.

Cosmetics, safety testing, Cutaneous irritancy, Cutaneous irritation, Cutaneous metabolism, Cutaneous toxicity, Cytoplasmic enzymes, Dermal absorption, Dermal irritancy, Dermal irritancy testing, Dermal irritation, Dermal penetration, Dermal permeation, ECVAM, EpiDerm, EpiSkin, European standards, Glutamate-oxaloacetate transferase, Glutathione-S-transferase, IL-1a, Interleukin (IL), Lactate dehydrogenase, Lauric acid, MTT, MTT ET-50 tissue viability assay, MTT assay, Mannitol, Metabolism, NADPH quinone reductase, Penetration, dermal, Percutaneous absorption, Percutaneous penetration, Personal care products, safety testing, Pre-validation, Prevalidation, Reproducibility, Reproducible, SDS treatment, Skin irritancy, Skin irritation, SkinEthic, Transdermal, Validation, Xenobiotics