Tissue Models
Basket-weave structure in the stratum corneum is an important factor for maintaining the physiological properties of human skin as studied using reconstructed human epidermis and tape stripping of human cheek skin
- TR Number: 862
- Authors: H. Goto, A. Tada, A. Ibe and Y. Kitajima
- Keywords: EPI-201, stratum corneum, basket-weave, corneo-desmosomes, intercellular lipids, mechanical properties, multilamellar lipid sheets, tactile sensor, desmoglein 1, lamellar lipids
- Materials Tested: oil-in-water emulsion, petroleum jelly, glycerin, butylene glycol, Cyclopentasiloxane, Quaternium-18 hectorite, polyethylene glycol-10 dimethicone, polyethylene glycol -2 stearate, stearic acid
The normal stratum corneum (SC) has an upper basket-weave (BW) pattern layer and a lower compact layer. The transition from compact to BW SC is well associated with a transition from diffuse to peripheral distributions of corneodesmosomes (CDs). The loss of transition from compact SC to BW SC appears to cause structural and barrier-function impairments.
Reference Application
- Respiratory toxicology
- MMPs
- Intestinal Permeation
- Bacterial colonization
- Translational toxicology
- Dry skin
- drug skin compatibility
- bacterial adherence
- Eye Irritation OECD TG 492
- Skin irritation
- Toxicity
- Cytokine analysis
- Immulogical research
- Nanoparticle toxicology/penetration
- Skin cancer
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- Electrolyzed Water
- Transbuccal drug delivery
- XtraMild skin mildness testing
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- Protein Expression
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- comet assay
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- Drug absorption
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- Toxicology
- Skin corrosion
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- anti-wrinkling
- RSMN micronucleus assay
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- artificial saliva
- Transbuccal permeation/penetration
- Permeation
- Infections
- Cosmetics
- Metabolism
- Mucous
- Respiratory infection
Reference Product
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