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EpiNasal

1092

Improving Intranasal Naloxone Delivery Using Excipients in a Tissue Model

Purpose: Intranasal delivery is an attractive route for systemic drug administration due to its non-invasiveness, rapid onset, avoidance of first pass metabolism, and patient comfort and compliance. However, drug absorption through the nasal mucosa faces several formulation challenges, including low permeability for hydrophilic and high-molecular-weight drugs, rapid mucociliary clearance, and enzymatic degradation in the nasal mucosa. […]
1041

Mucoadhesive chitosan-poly (lactic-co-glycolic acid) nanoparticles for intranasal delivery of quetiapine – Development & characterization in physiologically relevant 3D tissue models

Quetiapine hemifumarate (QF) delivery to the CNS via conventional formulations is challenging due to poor solubility and lower oral bioavailability (9 %). Similarly, many other second-generation antipsychotics, such as olanzapine, clozapine, and paliperidone, have also shown low oral bioavailability of <50 %. Hence, the present work was intended to formulate QF-loaded biodegradable PLGA-NPs with appropriate […]
1001

Antiviral activity of EIDD-1931 and Remdesivir against SARS-CoV-2 variants in a 3D mucociliary tissue models consisting of normal human-derived tracheal/bronchial (EpiAirway) and nasal (EpiNasal) epithelial cells

In vitro assays are an important early step to determine the potential antiviral activity of novel compounds. The antiviral efficacy of compounds is often evaluated in immortalized cell lines, which offer the advantage of cost effectiveness, ease of use, and reproducibility. However, these monolayer cell lines are not always predictive for cytotoxicity or in vivo […]
967

Replication and antiviral activity of MERS and SARS-CoV-2 variants in a highly specialized 3D mucociliary tissue model consisting of normal human-derived tracheal/bronchial epithelial cells

In vitro assays are an important early step to determine the potential antiviral activity of novel compounds. The antiviral efficacy of compounds is often evaluated in immortalized cell lines, which offer the advantage of cost effectiveness, ease of use, and reproducibility. However, these monolayer cell lines are not always predictive for cytotoxicity or in vivo […]
963

Organotypic 3D primary human nasal tissue model for toxicological studies

The nasal mucosa serves as the first line of defense against inhaled chemicals, drugs, and respiratory infections. Here we developed a novel in vitro primary human cell-based 3D human nasal epithelial tissue (NET) cultured on a cell culture insert with a porous (0.4 μm) membrane bottom at an air-liquid interface (ALI). The NET model was […]