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Intestinal barrier

994

Effects of Proteases from Pineapple and Papaya on Protein Digestive Capacity and Gut Microbiota in Healthy C57BL/6 Mice and Dose-Manner Response on Mucosal Permeability in Human Reconstructed Intestinal 3D Tissue Model

Cysteine proteases obtained from the stem of pineapple or papaya latex, bromelain and papain, respectively, exhibit a broad spectrum of beneficial effects on human health. However, their effects on gut microbiota composition or dose manner effects on the intestinal integrity of healthy tissue have not been evaluated. In this study, C57BL/6 young, healthy mice were […]
964

Primary Human Cell-Based 3D Colon Tissue Model for Toxicological Studies

The aim of this study was to reconstruct and characterize a primary cell based human 3D colon tissue model for the study of: 1) microbiome, 2) colorectal care product screening for their irritation potential, 3) safety and efficacy of anti-microbial products and colon-targeted drug candidates, and 4) inflammation. This study characterizes the structural features of […]
935

Particulate Matter Decreases Intestinal Barrier-Associated Proteins Levels in 3D Human Intestinal Model

Background: The gastrointestinal tract (GI) tract is one of the main organs exposed to particulate matter (PM) directly through ingestion of contaminated food or indirectly through inhalation. Previous studies have investigated the effects of chronic PM exposure on intestinal epithelia in vitro using Caco−2 cells and in vivo using mice. In this study, we hypothesized […]