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Intestinal barrier

1069

Human organotypic colon in vitro microtissue: unveiling a new window into colonic drug disposition

The purpose of this study was to evaluate EpiColon, a novel human organotypic 3D colon microtissue prototype, developed to assess colonic drug disposition, with a particular focus on permeability ranking, […]
994

Effects of Proteases from Pineapple and Papaya on Protein Digestive Capacity and Gut Microbiota in Healthy C57BL/6 Mice and Dose-Manner Response on Mucosal Permeability in Human Reconstructed Intestinal 3D Tissue Model

Cysteine proteases obtained from the stem of pineapple or papaya latex, bromelain and papain, respectively, exhibit a broad spectrum of beneficial effects on human health. However, their effects on gut […]
964

Primary Human Cell-Based 3D Colon Tissue Model for Toxicological Studies

The aim of this study was to reconstruct and characterize a primary cell based human 3D colon tissue model for the study of: 1) microbiome, 2) colorectal care product screening […]
935

Particulate Matter Decreases Intestinal Barrier-Associated Proteins Levels in 3D Human Intestinal Model

Background: The gastrointestinal tract (GI) tract is one of the main organs exposed to particulate matter (PM) directly through ingestion of contaminated food or indirectly through inhalation. Previous studies have […]