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Immulogical research

792

Endo-glucanase digestion of oat β-Glucan enhances Dectin-1 activation in human dendritic cells

Oat β-Glucans were studied for their immunological impact before and after enzymatic digestion in order to enhance the efficacy of oat β-Glucans for application in functional foods. Oat β-Glucan is reported to have minimal impact compared to its fungal counterpart in vitro. Digestion with endo-glucanase enhanced its efficacy towards stimulating MCP-1, RANTES, IL-8, and IL-4 production in human dendritic […]
418

EXPRESSION AND FUNCTION OF BACTERICIDAL/PERMEABILITY – INCREASING PROTEIN IN HUMAN GENITAL TRACT EPITHELIAL CELLS.

This study by researchers at Brigham and Women’s Hospital/Harvard Medical School demonstrated that Mattek’s EpiVaginal human cervico-vaginal tissue equivalent expresses bactericidal/permeability-increasing protein (BPI) and that this protein’s role in regulating bacterial colonization in the genital mucosa can be studied in vitro using EpiVaginal tissues. Genital tract epithelia regularly encounter and adapt to the existence of […]
432

THE EFFECTS OF IL-20 SUBFAMILY CYTOKINES ON RECONSTITUTED HUMAN EPIDERMIS SUGGEST POTENTIAL ROLES IN CUTANEOUS INNATE DEFENSE AND PATHOGENIC ADAPTIVE IMMUNITY IN PSORIASIS.

This study by researchers at Genentech demonstrated that Mattek’s EpiDerm human skin tissue equivalent can be used to study the immunopathology of psoriasis. IL-19, IL-20, IL-22, IL-24, and IL-26 are members of the IL-10 family of cytokines that have been shown to be up-regulated in psoriatic skin. Contrary to IL-10, these cytokines signal using receptor […]