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Genomics

268

USE OF DIFFERENTIAL DISPLAY-POLYMERASE CHAIN REACTION TO IDENTIFY GENES SELECTIVELY MODULATED BY CHEMICAL ALLERGENS IN RECONSTITUTED HUMAN EPIDERMIS.

In the screening of topical drugs, cosmetics and other chemicals for human use, it is very important, both from a safety and an economic point of view, to have biological markers to discriminate irritant and allergic contact dermatitis that have different impacts on human health. Owing to their anatomical location, keratinocytes are among the first […]
447

SYSTEMATIC IDENTIFICATION OF PROTEASES AND ANTI-PROTEASES IN DEVELOPING PRIMARY AIRWAY EPITHELIAL CELLS BY GLOBAL GENE EXPRESSION.

This study by researchers at Oxford University demonstrated that the genomics of human epithelial tissue development and differentiation can be investigated using standard global gene expression analysis techniques and Mattek’s in vitro human tissue equivalents, in this case EpiAirway in vitro human tissue equivalents, because all Mattek human tissue equivalents are produced from the appropriate […]
405

XENOBIOTIC METABOLIZING CAPABILITIES OF THE EPIDERM IN VITRO HUMAN SKIN EQUIVALENT.

This study by scientists at Procter and Gamble, the Institute for In Vitro Sciences (IIVS), and Mattek Corp. demonstrated that Mattek’s EpiDerm in vitro human skin tissue equivalent possesses numerous in vivo-like Xenobiotic Metabolizing Enzyme (XME) activities and is therefore useful for evaluating the dermal metabolism of drugs, cosmetics and environmental chemicals. The EpiDerm in […]
387

PROTECTING THE SKIN AGAINST OZONE.

This study by researchers at Arch Personal Care Products and Bioinnovation Laboratories demonstrated that Mattek’s EpiDerm and MelanoDerm in vitro human skin tissue equivalents could be used to prove that topical application of ozone stressed yeast extract protected the EpiDerm tissues against oxidative damage to both DNA and cholesterol, but not to the degradation of […]
366

ANALYSIS OF GLOBAL GENE EXPRESSION PROFILE CHANGES DURING THE DIFFERENTIATION OF THE EPIDERM™ IN VITRO HUMAN SKIN EQUIVALENT.

This study by researchers at Oxford University’s Wellcome Trust Centre for Human Genetics and the Oxford Centre for Gene Function demonstrated how Mattek’s EpiDerm in vitro human skin tissue equivalent can be used to provide a working knowledge of normal (human) epidermal differentiation at the gene level that could prove useful for advancing the understanding […]
132

CYTOKINE GENE EXPRESSION IN THE Mattek EPIDERM™ CULTURES.

Human skin equivalent cultures are currently being investigated as in vitro models to predict the contact sensitization potential of chemicals. The objective of the research presented here is to evaluate the constitutive expression of a panel of immunomodulatory cytokine genes and to determine the modulation of these genes following exposure to phorbol myristic acetate (PMA) […]
234

MICROARRAY ANALYSIS OF GENE EXPRESSION FOLLOWING EXPOSURE TO SKIN IRRITANTS.

Understanding of the mechanistic basis of the human skin irritation response is key to the development of relevant in vitro test systems for the predictive identification of skin irritation hazards. Recent progress in genomic technologies means that tools for the identification and investigation of important biochemical events in the processes of skin irritation are now […]
303

GENE EXPRESSION PROFILE OF TISSUE ENGINEERED SKIN SUBJECTED TO ACUTE BARRIER DISRUPTION.

The main function of the skin is to protect the body from infection, dehydration, and other environmental insults by creating an impermeable barrier of cornified cell layers, the stratum corneum. In contrast to cells in culture, tissue-engineeried skin equivalents contain well-developed basal, spinous, granular, and cornified cell layers providing an excellent model to study the […]