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Epithelial restitution

847

A Novel Assay for Evaluating Wound Healing in a Full-Thickness in vitro Human Skin Model

Wound healing is a fundamental process to re-establish tissue integrity and skin barrier function. A model of wound healing was created by introducing epidermal wounds in a full thickness in vitro human skin model (EpiDermFT) using a 3-mm punch biopsy and subsequently evaluated at multiple recovery time points. EpiDermFT exhibits stratified epidermal components and a […]
841

Hyperosmolal vaginal lubricants markedly reduce epithelial barrier properties in a three-dimensional vaginal epithelium model

Most of the widely used vaginal lubricants in the U.S. and Europe are strongly hyperosmolal, formulated with high concentrations of glycerol, propylene glycol, polyquaternary compounds or other ingredients that make these lubricants 4 to 30 times the osmolality of healthy vaginal fluid. Hyperosmolal formulations have been shown to cause marked toxicity to human colorectal epithelia in vivo, and […]
840

IL-22 Increases Permeability of Intestinal Epithelial Tight Junctions by Enhancing Claudin-2 Expression

Dysfunction of the epithelial barrier is a hallmark of inflammatory intestinal diseases. The intestinal epithelial barrier is maintained by expression of tight junctions that connect adjacent epithelial cells and seal the paracellular space. IL-22 is critical for the maintenance of intestinal barrier function through promoting antipathogen responses and regeneration of epithelial tissues in the gut. However, little is […]
762

ORGANOTYPIC HUMAN SMALL INTESTINAL TISSUE TO ASSESS EPITHELIAL RESTITUTION.

Purpose:  The intestinal epithelium (SMI) forms an important physiological barrier in the gastrointestinal tract but this barrier can be compromised by a wide range of substances including drugs, microbes, and dietary substances traveling through the lumen.  Since repeated epithelial damage or injury are implicated in intestinal disorders including inflammatory bowel diseases, rapid closure or resealing […]