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COPD

871

Dysregulated repair and inflammatory responses by e‐cigarette derived inhaled nicotine and humectant propylene glycol in a sex dependent manner in mouse lung

Nicotine inhalation via electronic cigarettes (e‐cigs) is an emerging concern. However, little is known about the acute toxicity in the lungs following inhalation of nicotine containing e‐cig aerosols. We hypothesized […]
835

In Vitro Human Airway Models for Study of Goblet Cell Hyperplasia and Mucus Production: Effects of Th2 Cytokines, Double-Stranded RNA, and Tobacco Smoke

Goblet cell hyperplasia (GCH) within the epithelium of the conducting airways is a common feature of human respiratory diseases, including asthma and chronic obstructive pulmonary disease. GCH can be initiated or […]
446

CYTOKINE-INDUCED GOBLET CELL HYPERPLASIA IN THE (EPIAIRWAY-FT) IN VITRO FULL-THICKNESS HUMAN AIRWAY MODEL.

This study by Mattek Corp. scientists demonstrated that Mattek’s EpiAirway-FT in vitro full thickness human airway tissue equivalent is superior to previous airway in vitro tissue equivalents because it provides […]
663

MECHANISMS OF GOBLET CELL HYPERPLASIA INDUCED BY SIMULATED VIRAL EXPOSURE OR TH2 CYTOKINES.

Introduction:  Goblet cell hyperplasia is a common feature of respiratory epithelial response to numerous environmental challenges (e.g. cigarette smoke, air pollution, viral infection) and is also commonly observed in respiratory […]
370

MICROARRAY EXPRESSION STUDIES ON AN IN VITRO MODEL OF HUMAN AIRWAY EPITHELIUM (EPIAIRWAY).

This study by researchers at the Wellcome Trust Centre for Human Genetics, Oxford University’s Centre for Gene Function and Mattek Corp. demonstrated how Mattek’s EpiAirway in vitro human tracheal/bronchial tissue […]
521

TISSUE ENGINEERED IN VITRO HUMAN AIRWAY MODELS (EPIAIRWAY) OF ASTHMA AND COPD.

This study by scientists at Mattek Corp. demonstrated that Mattek’s EpiAirway and EpiAirway-FT in vitro human tracheal/bronchial tissue equivalents can be produced from airway epithelium of diseased individuals, and that […]
332

AN IN VITRO MODEL OF FULL-THICKNESS HUMAN AIRWAY EPITHELIUM (EPIAIRWAY-FT) FOR STUDY OF EPITHELIUM/MATRIX INTERACTIONS.

In vitro models of airway epithelium (AE) have potential utility for study of diseases such as asthma and COPD, development of inhalable therapeutics, and toxicology of hazardous chemicals. However, degradation […]
731

APPLICATION OF ORGANOTYPIC IN VITRO HUMAN CELL CULTURE MODELS FOR RESEARCH AND DEVELOPMENT OF INHALATION PHARMACEUTICAL FORMULATIONS TARGETING THE PROXIMAL AIRWAYS.

Delivery of pharmaceuticals via inhalation is a potentially useful alternative to intravenous injection for drugs that are unstable or poorly absorbed after oral administration; for chronic disease conditions that require […]
591

CIGARETTE SMOKE ALTERS TISSUE INHIBITOR OF METALLOPROTEINASE 1 AND MATRIX METALLOPROTEINASE 9 LEVELS IN THE BASOLATERAL SECRETIONS OF HUMAN ASTHMATIC BRONCHIAL EPITHELIUM IN VITRO.

Background: Asthma, a major cause of chronic lung disease worldwide, has increased in prevalence in all age and ethnic groups, particularly in urban areas where cigarette smoking is common. Cigarette […]