Antioxidants

Protective effects of a comprehensive topical antioxidant against ozone‑induced damage in a reconstructed human skin model

Tropospheric ozone (O3) is a source of oxidative stress. This study examined the ability of a topical antioxidant (WEL-DS) to inhibit O3-mediated damage in a human epidermal skin model. Four groups of tissues (N = 24) were compared: Group 1 (control) were untreated and unexposed; Group 2 were untreated and exposed to O3 (0.4 ppm, […]

Novel antioxidants are not toxic to normal tissues but effectively kill cancer cells

Free radicals are formed as a result of cellular processes and play a key role in predisposition to and development of numerous diseases and of premature aging. Recently, we reported the syntheses of a number of novel phenolic antioxidants for possible application in food industry. In the present study, analyses of the cellular processes and […]

INHIBITING THE EFFECTS OF OXIDATIVE STRESS VIA TOPICALLY APPLIED ANTIOXIDANT FORMULATIONS.

VISUALIZATION AND CHARACTERIZATION OF UVB-INDUCED REACTIVE OXYGEN SPECIES IN A HUMAN SKIN EQUIVALENT MODEL.

This study by researchers at Procter and Gamble, Kyoto University and Kyoto Pharmaceutical University demonstrated that Mattek’s EpiDerm in vitro 3-D human skin tissue equivalent is useful for visualizing the production of UVB-induced Reactive Oxygen Species (ROS) in real-time, and for evaluating the efficacy of topically applied anti-oxidative compounds to suppress ROS generation and attenuate […]