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EpiOcular

1094

Defined approaches to predict GHS and EPA classifications for ocular irritation potential of agrochemical formulations

Introduction: Regulations require that agrochemicals be labeled to indicate potential harmful effects caused by exposure. The in vivo Draize rabbit eye test has historically been the standard method used to assess the eye irritation or corrosion potential of chemical substances. However, as scientific confidence has been established for certain in chemico, in vitro, and ex vivo […]
1093

Performance of the DASF compared to other combinations of OECD NAMs for eye hazard identification of surfactants

Currently, the OECD has adopted three defined approaches (DAs) for eye hazard identification of non-surfactant liquids and solids (TG 467) according to the three UN GHS categories. We are now expanding the applicability domain with a new DA for chemicals having surfactant properties (DASF). It is based on a combination of recombinant human cornea-like epithelium […]
1064

Evaluation of Biocompatible Materials for Enhanced Mesenchymal Stem Cell Expansion: Collagen-Coated Alginate Microcarriers and PLGA Nanofibers

Mesenchymal stem cells (MSCs) hold significant potential in regenerative medicine, tissue engineering, and cultivated meat production. However, large-scale MSC production is limited by their need for surface adherence during growth. This study evaluates two biocompatible materials—collagen-coated alginate microcarriers and polylactic-co-glycolic acid (PLGA) nanofibers—as novel growth substrates to enhance MSC proliferation. Physicochemical characterization confirmed successful collagen […]