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January 18, 2021

Bypassing P-glycoprotein mediated efflux of afatinib by cyclodextrin complexation – Evaluation of intestinal absorption and anti-cancer activity

A cyclodextrin complex of afatinib, a FDA-approved pan–ErbB inhibitor and known P-gp substrate, was developed to enhance...

January 11, 2021

Influenza A Virus Infection of Human Respiratory Cells Induces Primary MicroRNA Expression*

The cellular response to virus infection is initiated by recognition of the invading pathogen and subsequent changes...

January 11, 2021

A Systems Biology Approach Reveals the Dose- and Time-Dependent Effect of Primary Human Airway Epithelium Tissue Culture After Exposure to Cigarette Smoke In Vitro

To establish a relevant in vitro model for systems toxicology-based mechanistic assessment of environmental stressors such as...

January 11, 2021

In vitro evaluation of immunobiological activity of simple mannolipids

Immunomodulation, cytotoxicity and anti-cancer activity of selected amphiphilic non-ionic (thio)alkyl α-Dmannosides (with aglycone of C6-C12) were investigated...

December 10, 2020

Novel cytokine marker available for skin irritation testing of medical devices using reconstructed human epidermis models

In biological safety evaluation of medical devices, false-negative results have been observed during skin irritation testing using...