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Tumor invasion

669

EVALUATION OF ANTI-INFLAMMATORY AND ATROPHOGENIC EFFECTS OF GLUCOCORTICOIDS ON RECONSTRUCTED HUMAN SKIN.

Topical glucocorticoids (GCs) are extensively used in the treatment of inflammatory skin diseases. However, their long-term use is often accompanied by severe and eventually irreversible adverse effects, with atrophy being the most important limitation. Currently, most non-clinical studies involve animal testing, so the results are not always representative of the situation in humans. The aim […]
754

THE INCLUSION COMPLEX OF 4-HYDROXYNONENAL WITH A POLYMERIC DERIVATIVE OF Β-CYCLODEXTRIN ENHANCES THE ANTITUMORAL EFFICACY OF THE ALDEHYDE IN SEVERAL TUMOR CELL LINES AND IN A THREE-DIMENSIONAL HUMAN MELANOMA MODEL.

4-Hydroxynonenal (HNE) is the most studied end product of the lipoperoxidation process, by virtue of its relevant biological activity. The antiproliferative and proapoptotic effects of HNE have been widely demonstrated in a great variety of tumor cell types in vitro. Thus, it might represent a promising new molecule in anticancer therapy strategies. However, the extreme […]
734

GOSSYPIN AS A NOVEL SELECTIVE DUAL INHIBITOR OF V-RAF MURINE SARCOMA VIRAL ONCOGENE HOMOLOG B1 AND CYCLIN-DEPENDENT KINASE 4 FOR MELANOMA

Mutation in the BRAF gene (BRAFV600E) exists in nearly 70% of human melanomas. Targeted therapy against BRAFV600E kinase using a recently identified RAF-selective inhibitor, PLX4032, has been successful in early clinical trials. However, in patients with the normal BRAF allele (wild-type), PLX4032 is protumorigenic. This conundrum identifies the unmet need for novel therapeutic agents to […]
728

THE ROLE OF MELANOMA TUMOR-DERIVED NITRIC OXIDE IN THE TUMOR INFLAMMATORY MICROENVIRONMENT: ITS IMPACT ON THE CHEMOKINE EXPRESSION PROFILE, INCLUDING SUPPRESSION OF CXCL10.

Melanoma appears to be heterogeneous in terms of its molecular biology, etiology and epidemiology. We previously reported that the expression of inducible nitric-oxide synthase (iNOS) in melanoma tumor cells is strongly correlated with poor patient survival. Therefore, we hypothesized that nitric oxide (NO) produced by iNOS promotes the melanoma inflammatory tumor microenvironment associated with poor […]