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Transbuccal permeation/penetration

903

Transmucosal Delivery of Nicotine in Combination with Tincture of Benzoin Inhibits Apoptosis

Background and Objective – The aim of this study was to test the hypothesis that tincture of benzoin (TOB) facilitates immediate transmucosal nicotine absorption while simultaneously promoting a safe and sustained delivery of the nicotine. Methods – In combination with TOB, nicotine toxicity and diffusion across human mucosal cells were measured using a 3-D human […]
855

Behaviour of Silver Nanoparticles in Simulated Saliva and Gastrointestinal Fluids

Continuously increasing application of silver nanoparticles (AgNPs) requires information on their safety and performance under biological conditions. Assessment of AgNPs in biological systems is also related to availability of robust toxicological methods for evaluation of toxic potential of AgNPs and information on their physicochemical state. Silver nanoparticles were subjected to action of simulated saliva, gastric […]
799

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures

Smoking has been associated with diseases of the lung, pulmonary airways and oral cavity. Cytologic, genomic and transcriptomic changes in oral mucosa correlate with oral preneoplasia, cancer and inflammation (e.g. periodontitis). Alteration of smoking-related gene expression changes in oral epithelial cells is similar to that in bronchial and nasal epithelial cells. Using a systems toxicology approach, we have previously […]
551

HIV TYPE 1 FAILS TO TRIGGER INNATE IMMUNE FACTOR SYNTHESIS IN DIFFERENTIATED ORAL EPITHELIUM.

This study by scientists at Prince of Songkla University (Thailand), the University of Washington, Fred Hutchinson Cancer Research Center and Mattek Corp. demonstrated that Mattek’s EpiOral in vitro 3-D human buccal (inner cheek) tissue equivalent can be used to model the in vivo response to HIV-1 virus exposure. The oral mucosa is relatively resistant to […]