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Toxicology

912

A Systems Biology Approach Reveals the Dose- and Time-Dependent Effect of Primary Human Airway Epithelium Tissue Culture After Exposure to Cigarette Smoke In Vitro

To establish a relevant in vitro model for systems toxicology-based mechanistic assessment of environmental stressors such as cigarette smoke (CS), we exposed human organotypic bronchial epithelial tissue cultures at the […]
911

In vitro evaluation of immunobiological activity of simple mannolipids

Immunomodulation, cytotoxicity and anti-cancer activity of selected amphiphilic non-ionic (thio)alkyl α-Dmannosides (with aglycone of C6-C12) were investigated in vitro in human cervix epitheloid carcinoma cell line HeLa, murine melanoma cancer […]
857

In vitro biocompatibility study approaches to evaluate the safety profile of electrolyzed water for skin and eye

Electrolyzed water (EW) is a widely used disinfectant agent with high oxidation–reduction potential (ORP). Although EW has been used in many areas, such as food hygiene, agriculture, and animal husbandry, […]
855

Behaviour of Silver Nanoparticles in Simulated Saliva and Gastrointestinal Fluids

Continuously increasing application of silver nanoparticles (AgNPs) requires information on their safety and performance under biological conditions. Assessment of AgNPs in biological systems is also related to availability of robust […]
3522

Toxicity of Food Contact Paper Evaluated by Combined Biological and Chemical Methods

The study was focused on assessment of potential health risks of paper-based food contact materials (FCMs) in a step-wise approach using three toxicological bioassays in vitro and chemical analyses of […]
837

Prevalidation of an Acute Inhalation Toxicity Test Using the EpiAirway In Vitro Human Airway Model

Introduction: Knowledge of acute inhalation toxicity potential is important for establishing safe use of chemicals and consumer products. Inhalation toxicity testing and classification procedures currently accepted within worldwide government regulatory systems rely […]
832

Skin Damage Mechanisms Related to Airborne Particulate Matter Exposure

Epidemiological studies suggest a correlation between increased airborne particulate matter (PM) and adverse health effects. The mechanisms of PM-health effects are believed to involve oxidative stress and inflammation. To evaluate the ability […]
810

Health Safety of Food Contact Paper Evaluated by in vitro Toxicological Methods

Paper and paperboard are widely used as food packaging materials intended for direct contact with foodstuffs and have to comply with a basic set of criteria concerning safety. A number of […]
809

Application of Mattek In Vitro Reconstructed Human Skin Models for Safety, Efficacy Screening, and Basic Preclinical Research

During the past three decades, great progress has been achieved in the development of in vitro reconstructed human epidermal (RhE) tissue models. This technology is now available via various manufacturers of […]
842

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures

Smoking has been associated with diseases of the lung, pulmonary airways and oral cavity. Cytologic, genomic and transcriptomic changes in oral mucosa correlate with oral preneoplasia, cancer and inflammation (e.g. periodontitis). Alteration […]
794

Development of an in vitro cytotoxicity model for aerosol exposure using 3D reconstructed human airway tissue; application for assessment of e-cigarette aerosol

Development of physiologically relevant test methods to analyse potential irritant effects to the respiratory tract caused by e-cigarette aerosols is required. This paper reports the method development and optimisation of an acute […]
654

ORGANOTYPIC IN VITRO HUMAN EPITHELIAL MODELS WITH ENGINEERED TOXICOLOGIC REPORTER FUNCTIONS.

3D organotypic in vitro human epithelial models including skin (e.g. EpiDerm, EpiDerm-FT) and airway (e.g. EpiAirway, EpiAirway-FT) are important advances over traditional monolayer cell culture models. For toxicology applications, these […]
300

IN VITRO MODELS OF FULL-THICKNESS HUMAN SKIN (EPIDERMFT™) AND AIRWAY EPITHELIUM (EPIAIRWAYFT™) FOR TOXICOLOGY AND DRUG DEVELOPMENT APPLICATIONS.

In vitro models of human skin and airway epithelia have potential applications in toxicology studies involving chemical warfare agents, environmental chemicals or consumer products, as well as in development of […]
631

FILTER-WELL TECHNOLOGY FOR ADVANCED THREE-DIMENSIONAL CELL CULTURE: PERSPECTIVES FOR RESPIRATORY RESEARCH.

Cell culture has long been a valuable tool for studying cell behaviour. Classical plastic substrates are two-dimensional, and usually promote cellular proliferation and inhibit differentiation. Understanding cell behaviour within complex […]
556

ASSESSMENT OF DERMAL TOXICITY OF NANOSILICA USING CULTURED KERATINOCYTES, A HUMAN SKIN EQUIVALENT MODEL AND AN IN VIVO MODEL.

This study by researchers at Korea University College of Medicine and the National Institute of Toxicological Research (Korea) demonstrated how Mattek’s EpiDerm in vitro 3-D human skin tissue equivalent can […]
546

OXIDATIVE STRESS AND INFLAMMATORY RESPONSE IN DERMAL TOXICITY OF SINGLE-WALLED CARBON NANOTUBES.

This study by researchers at PPRB/NIOSH, West Virginia University and the University of Pittsburgh demonstrated that Mattek’s EpiDermFT full-thickness in vitro 3-D human skin tissue equivalent can be used to […]
838

SAFETY EVALUATION OF NANOSILVER USING RECONSTRUCTED HUMAN GIT TISSUES

In our pilot study focused on safety evaluation of nanosilver three novel commercially available  reconstructed human  tissues were used for mimicking the human gastrointestinal tract (GIT). The evaluated endpoints included […]