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Smoker

846

An In Vitro Versus In Vivo Toxicogenomic Investigation of Prenatal Exposures to Tobacco Smoke

Approximately 1 million women smoke during pregnancy despite evidence demonstrating serious juvenile and/ or adult diseases being linked to early-life exposure to cigarette smoke. Susceptibility could be determined by factors in previous generations, that is, prenatal or ‘‘maternal’’ exposures to toxins. Prenatal exposure to airborne pollutants such as mainstream cigarette smoke has been shown to […]
799

In vitro systems toxicology approach to investigate the effects of repeated cigarette smoke exposure on human buccal and gingival organotypic epithelial tissue cultures

Smoking has been associated with diseases of the lung, pulmonary airways and oral cavity. Cytologic, genomic and transcriptomic changes in oral mucosa correlate with oral preneoplasia, cancer and inflammation (e.g. periodontitis). Alteration of smoking-related gene expression changes in oral epithelial cells is similar to that in bronchial and nasal epithelial cells. Using a systems toxicology approach, we have previously […]
740

HUMAN BRONCHIAL EPITHELIAL CELLS EXPOSED IN VITRO TO CIGARETTE SMOKE AT THE AIR-LIQUID INTERFACE RESEMBLE BRONCHIAL EPITHELIUM FROM HUMAN SMOKERS.

Organotypic culture of human primary bronchial epithelial cells is a useful in vitro system to study normal biological processes and lung disease mechanisms, to develop new therapies, and to assess the biological perturbations induced by environmental pollutants. Herein, we investigate whether the perturbations induced by cigarette smoke (CS) and observed in the epithelium of smokers’ […]
642

IN VITRO EXPOSURE OF ORGANOTYPICAL 3D EPITHELIAL TISSUES TO CIGARETTE SMOKE AS A POTENTIAL ALTERNATIVE TO RODENT INHALATION STUDIES.

Airway epithelium is the initial barrier affected by toxic gases or particles in the atmosphere, such as cigarette smoke (CS), which induces, among other things, inflammatory processes that can lead to COPD and tissue remodeling (Takizawa 2001, Yoshida 2007). Here we describe an in vitro test system that examines the toxicological effects of single or […]
562

ESTABLISHMENT OF A 3D AIRWAY MODEL FOR RESPIRATORY INFECTION.

Summary: Battelle utilizes the EpiAirway 3D respiratory tract tissue model for respiratory pathogen infection studies and for comparison of response to infection in the 3D in vitro tissue models derived from normal, asthmatic, smoker, and chronic obstructive pulmonary disease (COPD) donor tissues. Battelle has demonstrated that the EpiAirway tissues can be cultured for extended periods […]