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Skin hydration

957

In vitro and in vivo evaluation of a moisture treatment cream containing three critical elements of natural skin moisturization

Objectives: To evaluate skin barrier and hydration effects of a new rebalancing moisture treatment (TRMT) and to assess efficacy and tolerability in subjects with photodamaged skin. Methods: In an epidermal skin model, tissues (n = 5/group) were topically treated with 25 μL of TRMT, 25 μL of a market-leading moisturizer (MLM), or untreated for 60 […]
894

Anti-Aging Potentials of Methylene Blue for Human Skin Longevity

Oxidative stress is the major cause of skin aging that includes wrinkles, pigmentation, and weakened wound healing ability. Application of antioxidants in skin care is well accepted as an effective approach to delay the skin aging process. Methylene blue (MB), a traditional mitochondrial-targeting antioxidant, showed a potent ROS scavenging efficacy in cultured human skin fibroblasts […]
880

Unlocking Mother Nature’s Building Blocks

Just as the foundation of water is hydrogen and oxygen, the foundation of plants and trees are cellulose and lignin. These universal materials act as Mother Nature’s building blocks and have proven critical to botanical viability, enabling growth and protecting against environmental stresses. Historically, scientists have failed to extract cellulose and lignin in the form […]
873

Reconstructed Human Epidermis Predicts Barrier-Improving Effects of Lactococcus lactis Emulsion in Humans

Background/Aims: The skin provides protection against chemical, physical, and biological stressors, yet the skin morphology changes over the course of life. These changes might affect the skin barrier function and facilitate the onset of age-related diseases. Since orally applied lactic acid bacteria ameliorate signs of aged and atopic skin, we investigated the effects of a […]
862

Basket-weave structure in the stratum corneum is an important factor for maintaining the physiological properties of human skin as studied using reconstructed human epidermis and tape stripping of human cheek skin

The normal stratum corneum (SC) has an upper basket-weave (BW) pattern layer and a lower compact layer. The transition from compact to BW SC is well associated with a transition from diffuse to peripheral distributions of corneodesmosomes (CDs). The loss of transition from compact SC to BW SC appears to cause structural and barrier-function impairments.
856

A series of in vitro and human studies of a novel lip cream formulation for protecting against environmental triggers of recurrent herpes labialis

Purpose: These studies describe the testing of a novel, daily-use lip cream designed for individuals with lips prone to recurrent herpes labialis (RHL) that protects against environmental triggers. Subjects and methods: In vitro occlusive and in vitro and in vivo photoprotection analyses, a characterization of normal vs dry lips, and a randomized, evaluator-blinded, clinical trial […]
634

UNDERSTANDING METABOLIC PATHWAYS FOR SKIN ANTI-AGING.

Global gene expression profiling provides a useful means to identify key aspects of the skin aging process, and provides Information to help develop new skin technologies. Important aspects of skin aging that can be addressed Include skin hydration, barrier, matrix, pigmentation and antioxidant capacity. Human skin equivalent cultures allow topical application of test compounds, combinations […]
510

TOPICAL N-ACETYL GLUCOSAMINE AND NIACINAMIDE INCREASE HYALURONAN IN VITRO.

This study by researchers at Procter & Gamble Co. demonstrated how Mattek’s EpiDermFT full-thickness in vitro human skin tissue equivalent can be used to study the expression of a major extracellular matrix component of human skin (hyaluronan) when N-acetyl glucosamine and niacinamide are applied to the apical surface of the tissues simulating topical application on […]