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Skin differentiation

893

Nell1 Protein Reduces the Number of Sunburned Cells and Modulates the Inflammatory Response after UV-induced Damage in a 3D Human Skin Model

NELL1 is a novel signaling protein that mediates tissue growth and maturation during fetal development and stimulates tissue healing post-injury in adult tissues. NELL1 promotes the production of a regenerative (fetal type) extracellular matrix (ECM) that provides the structural and communication framework for several processes essential to tissue repair and regeneration such as cell proliferation, […]
892

Nicotinamide Metabolism Modulates the Proliferation/Differentiation Balance and Senescence of Human Primary Keratinocytes

Nicotinamide (NAM) is the main precursor of nicotinamide adenine dinucleotide (NAD+), a coenzyme essential for DNA repair, glycolysis, and oxidative phosphorylation. NAM has anti-aging activity on human skin, but the underlying mechanisms of action are unclear. Using 3-dimensional organotypic skin models, we show that NAM inhibits differentiation of the upper epidermal layers and maintains proliferation […]