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Ocular irritation

1094

Defined approaches to predict GHS and EPA classifications for ocular irritation potential of agrochemical formulations

Introduction: Regulations require that agrochemicals be labeled to indicate potential harmful effects caused by exposure. The in vivo Draize rabbit eye test has historically been the standard method used to assess […]
1093

Performance of the DASF compared to other combinations of OECD NAMs for eye hazard identification of surfactants

Currently, the OECD has adopted three defined approaches (DAs) for eye hazard identification of non-surfactant liquids and solids (TG 467) according to the three UN GHS categories. We are now […]
997

Determination and Sub-categorization of Ocular Irritants Using the EpiOcular Tissue Model – Prediction Models for Liquids and Solids

Assessment of serious eye damage/eye irritation originally involved the use of laboratory animals (OECD TG 405). In 2015, a new test guideline (OECD TG 492) was accepted which enables the […]
996

Health safety of parabens evaluated by selected in vitro methods

Seven selected parabens (4 allowed, 3 banned in cosmetics) were tested in order to confirm and expand historical data on their toxicological properties and safety. The aim was to apply […]
921

In vitro reconstructed 3D corneal tissue models for ocular toxicology and ophthalmic drug development

Testing of all manufactured products and their ingredients for eye irritation is a regulatory requirement. In the last two decades, the development of alternatives to the in vivo Draize eye […]
911

In vitro evaluation of immunobiological activity of simple mannolipids

Immunomodulation, cytotoxicity and anti-cancer activity of selected amphiphilic non-ionic (thio)alkyl α-Dmannosides (with aglycone of C6-C12) were investigated in vitro in human cervix epitheloid carcinoma cell line HeLa, murine melanoma cancer […]
864

Oxidative stress in corneal injuries of different origin: Utilization of 3D human corneal epithelial tissue model

The purpose of the current work was to utilize a three dimensional (3D) corneal epithelial tissue model to study dry eye disease and oxidative stress-related corneal epithelial injuries for the […]
824

CON4EI: EpiOcular™ Eye Irritation Test (EpiOcular™ EIT) for hazard identification and labeling of eye irritating chemicals

Assessment of the acute eye irritation potential is part of the international regulatory requirements for testing of chemicals. The objective of the CON4EI project was to develop tiered testing strategies for […]
812

Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay

Background: Assessment of eye irritation hazard has long been a core requirement in any chemical legislation. Nevertheless, publications focusing on the eye damaging potential of nanomaterials are scarce. Traditionally, eye irritation testing […]
749

OCULAR TOXICITY OF AUTHENTIC LUNAR DUST.

Background: Dust exposure is a well-known occupational hazard for terrestrial workers and astronauts alike and will continue to be a concern as humankind pursues exploration and habitation of objects beyond […]
729

COSMETICS EUROPE MULTI-LABORATORY PRE-VALIDATION OF THE EPIOCULAR™ RECONSTITUTED HUMAN TISSUE TEST METHOD FOR THE PREDICTION OF EYE IRRITATION.

Cosmetics Europe, The Personal Care Association (known as Colipa before 2012), conducted a program of  technology transfer andwithin/between laboratory reproducibility of Mattek Corporation’s EpiOcular™  Eye Irritation Test (EIT) as one […]
673

IN-HOUSE VALIDATION OF THE EPIOCULAR™ EYE IRRITATION TEST AND ITS COMBINATION WITH THE BOVINE CORNEAL OPACITY AND PERMEABILITY TEST FOR THE ASSESSMENT OF OCULAR IRRITATION.

In 2009, the Bovine Corneal Opacity and Permeability (BCOP) test was accepted by the regulatory bodies for the identification of corrosive and severe ocular irritants (Global Harmonised System [GHS] Category […]
706

PREDICTING EYE IRRITATION OF AGROCHEMICAL FORMULATIONS ACCORDING TO DIFFERENT CLASSIFICATION SCHEMES BY IN VITRO METHODS (BOVINE CORNEAL OPACITY AND PERMEABILITY AND EPIOCULAR EYE IRRITATION TEST).

The bovine corneal opacity and permeability (BCOP) test has been adopted by OECD for the identification of corrosive and severe ocular irritants (GHS category 1) for single component substances and […]
746

N,N-DICHLORO-2, 2-DIMETHYLTAURINE, N-MONOCHLORO-2, 2-DIMETHYLTAURINE, AND N-CHLOROTAURINE ARE SAFE AND EFFECTIVE BACTERICIDAL AGENTS IN CORNEAL MODELS.

Background: N-chlorotaurine, NVC-422 (N,N-dichloro-dimethyltaurine) and NVC-612 (N-monochloro-dimethyltaurine) are potent anti-infective agents useful for the treatment of conjunctivitis and keratitis.  The aim of this study is to show that these compounds […]