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Nanotoxicology

881

Use of EpiAlveolar Lung Model to Predict Fibrotic Potential of Multiwalled Carbon Nanotubes

Expansion in production and commercial use of nanomaterials increases the potential human exposure during the lifecycle of these materials (production, use, and disposal). Inhalation is a primary route of exposure to nanomaterials; therefore it is critical to assess their potential respiratory hazard. Herein, we developed a three-dimensional alveolar model (EpiAlveolar) consisting of human primary alveolar […]
855

Behaviour of Silver Nanoparticles in Simulated Saliva and Gastrointestinal Fluids

Continuously increasing application of silver nanoparticles (AgNPs) requires information on their safety and performance under biological conditions. Assessment of AgNPs in biological systems is also related to availability of robust toxicological methods for evaluation of toxic potential of AgNPs and information on their physicochemical state. Silver nanoparticles were subjected to action of simulated saliva, gastric […]
852

Genetic toxicity assessment of engineered nanoparticles using a 3D in vitro skin model (EpiDerm™)

Background: The rapid production and incorporation of engineered nanomaterials into consumer products alongside research suggesting nanomaterials can cause cell death and DNA damage (genotoxicity) makes in vitro assays desirable for nanosafety screening. However, conflicting outcomes are often observed when in vitro and in vivo study results are compared, suggesting more physiologically representative in vitro models […]
814

Cytotoxicity of copper (II) oxide nanoparticles in rat and human intestinal cell models

Copper (II) oxide nanoparticles (CuO NPs) have a variety of commercial applications ranging from catalysts to semiconductors. There is a potential for human oral exposure to CuO NPs following accidental or intentional ingestion, hand-to-mouth activity, or mucociliary transport following inhalation. CuO NPs are toxic to aquatic organisms but their mammalian toxicity is less well known. […]
812

Eye irritation testing of nanomaterials using the EpiOcular™ eye irritation test and the bovine corneal opacity and permeability assay

Background: Assessment of eye irritation hazard has long been a core requirement in any chemical legislation. Nevertheless, publications focusing on the eye damaging potential of nanomaterials are scarce. Traditionally, eye irritation testing was performed using rabbits. The OECD Test Guideline 437 Bovine Corneal Opacity and Permeability (BCOP) test method allows determining severely irritating substances without animals, and the […]
478

INITIAL IN VITRO SCREENING APPROACH TO INVESTIGATE THE POTENTIAL HEALTH AND ENVIRONMENTAL HAZARDS OF ENVIROX™ – A NANOPARTICULATE CERIUM OXIDE DIESEL FUEL ADDITIVE.

This study by scientists at Oxonica, Product Assessment & Regulatory Compliance, and SafePharm Laboratories Ltd. demonstrated that Mattek’s EpiDerm in vitro tissue model system can be used to determine the skin irritation potential of formulations containing nanoparticles. Nanotechnology is the new industrial revolution of the 21st Century as the various processes lead to radical improvements […]
347

THE USE OF FLUORESCENTLY LABELED NANOPARTICLES TO DETERMINE THE EFFECT OF PARTICLE SIZE ON TRANSLOCATION FROM THE LUNG.

Nanoparticles or ultrafine particles, are particles generally considered to be less than 100nm in size. These particles have been implicated in morbidity and other adverse reactions. Due to their small size, these particles may translocate from the lung to remote sites such as the heart, liver, brain or other extrapulmonary organs after inhalation exposure. Additionally, […]
775

SAFETY EVALUATION OF NANOSILVER USING RECONSTRUCTED HUMAN GIT TISSUES

In our pilot study focused on safety evaluation of nanosilver three novel commercially available  reconstructed human  tissues were used for mimicking the human gastrointestinal tract (GIT). The evaluated endpoints included tissue viability, cytokine release and penetration of silver into the tissue culture medium. The results confirmed no adverse effect of nanosilver on the viability of […]