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Micronucleus Assay

1090

Micronucleus Induction by 5-Methoxypsoralen in the Photo Reconstructed Skin Micronucleus Assay: Development of a Human-Relevant NAM for Identifying Photo-genotoxic Substances

To address a lack of suitable non-animal tools to screen novel ingredients in personal care products for mutagenic/clastogenic activity after solar light exposure, we initiated a three-phase program to develop a new approach methodology (NAM) which integrates established UVA/UVB/visible light (UV/vis) photo-activation techniques to the reconstructed skin micronucleus (RSMN) assay. The first phase of the […]
1071

Qualification of the human Reconstructed Intestine Micronuclei Cytome assay for site-of-contact genotoxic hazard identification

While valuable for hazard identification, in vitro genotoxicity tests that are conducted in 2D monolayer cell cultures possess limitations to accurately envisage in vivo outcomes and may result in unnecessary follow-up in vivo studies. One limitation is their relevance to actual human exposure and the assessment of genotoxicity in tissues representative of “sites-of-first-contact with genotoxic […]