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Micronucleus Assay

1090

Micronucleus Induction by 5-Methoxypsoralen in the Photo Reconstructed Skin Micronucleus Assay: Development of a Human-Relevant NAM for Identifying Photo-genotoxic Substances

To address a lack of suitable non-animal tools to screen novel ingredients in personal care products for mutagenic/clastogenic activity after solar light exposure, we initiated a three-phase program to develop […]
1071

Qualification of the human Reconstructed Intestine Micronuclei Cytome assay for site-of-contact genotoxic hazard identification

While valuable for hazard identification, in vitro genotoxicity tests that are conducted in 2D monolayer cell cultures possess limitations to accurately envisage in vivo outcomes and may result in unnecessary […]
963

Organotypic 3D primary human nasal tissue model for toxicological studies

The nasal mucosa serves as the first line of defense against inhaled chemicals, drugs, and respiratory infections. Here we developed a novel in vitro primary human cell-based 3D human nasal […]
962

Development of reconstructed intestinal micronucleus cytome (RICyt) assay in 3D human gut model for genotoxicity assessment of orally ingested substances

The micronucleus (MN) assay is widely used as part of a battery of tests applied to evaluate the genotoxic potential of chemicals, including new food additives and novel food ingredients. […]
1000

Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays

In vitro test batteries have become the standard approach to determine the genotoxic potential of substances of interest across industry sectors. While useful for hazard identification, standard in vitro genotoxicity […]
901

The 3D reconstructed skin micronucleus assay: considerations for optimal protocol design

Implementation of the seventh amendment to the EU Cosmetics Directive has driven much research into suitable in vitro alternative assays to support satisfactory risk assessments. One such assay is the […]
920

Validation of the In Vitro Reconstructed Skin Micronucleus Assay as a Potential Animal Alternative for Fragrance Materials

The in vitro reconstructed skin micronucleus assay is a skin-based assay which measures the clastogenicity and aneugenicity potential of chemical materials and mixtures. Reconstructed skin models are prepared from primary human cells and […]
807

The EpiDerm 3D human reconstructed skin micronucleus (RSMN) assay: Historical control data and proof of principle studies for mechanistic assay adaptations

The in vitro human reconstructed skin micronucleus (RSMN) assay in EpiDerm is a promising novel animal alternative for evaluating genotoxicity of topically applied chemicals. It is particularly useful for assessing […]