Microbicides

Surfactant Protein D Reverses the Gene Signature of Transepithelial HIV-1 Passage and Restricts the Viral Transfer Across the Vaginal Barrier

Effective prophylactic strategy against the current epidemic of sexually transmitted HIV-1 infection requires understanding of the innate gatekeeping mechanisms at the genital mucosa. Surfactant protein D (SP-D), a member of […]

Novel Vaginal Microflora Colonization Model Providing New Insight into Microbicide Mechanism of Action

Several broad-spectrum microbicides, including cellulose sulfate (CS), have passed conventional preclinical and phase I clinical safety evaluation and yet have failed to protect women from acquiring IDV -1 in phase […]

PRECLINICAL EVALUATION OF LIME JUICE AS A TOPICAL MICROBICIDE CANDIDATE.

This study by researchers in the CONRAD (Contraceptive Research and Development) Program at Eastern Virginia Medical School and at St. George’s University/London demonstrated how Mattek’s EpiVaginal in vitro human cervico-vaginal […]

CONCORDANCE BETWEEN DIFFERENT IN VITRO CULTURE MODELS DESIGNED TO PREDICT VAGINAL IRRITATION AND/OR TOXICITY.

The safety profile of potential microbicides is equally, if not more important than anti-HIV activity. At the very least, candidates must not impair natural defences against HIV-1 infection or cause […]

STUDIES ON VAGINAL INNATE IMMUNITY IN THE EPIVAGINAL MODEL SYSTEM.

As stated in the “Conclusions” section, this study by Mattek Corp. scientists demonstrated that the EpiVaginal human ectocervical-vaginal tissue equivalent provided valuable information on molecular mechanisms of vaginal innate immunity, […]

RECONSTRUCTION OF VAGINAL TISSUE MODEL FOR HIV INFECTION.

The HIV/AIDS epidemic is continuing to escalate worldwide and it is estimated that through the year 2000, more than 34 million people have already been infected with the virus. Daily, […]

THE RETROCYCLIN ANALOGUE RC-101 PREVENTS HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 INFECTION OF A MODEL HUMAN CERVICOVAGINAL TISSUE CONSTRUCT.

This study by researchers at the University of Central Florida, University of Pittsburgh and UCLA School of Medicine demonstrated that Mattek’s EpiVaginal human vaginal-ectocervical tissue equivalent can be used to […]

ORGANOTYPIC HUMAN VAGINAL-ECTOCERVICAL TISSUE MODEL FOR IRRITATION STUDIES OF SPERMICIDES, MICROBICIDES, AND FEMININE-CARE PRODUCTS.

This study by scientists at Boston University School of Medicine and Mattek Corp. demonstrated that Mattek’s EpiVaginal in vitro human cervico-vaginal tissue equivalent is a highly reproducible, non-animal means to […]

HUMAN VAGINAL—ECTOCERVIAL TISSUE MODEL TO TEST THE IRRITATION POTENTIAL OF CONTRACEPTIVE AND VAGINAL-CARE PRODUCTS.

RECONSTRUCTED HUMAN VAGINAL-ECTOCERVICAL TISSUE MODELS.

Acquired immunodeficiency syndrome (AIDS) is now the fourth most common cause of death worldwide. In the last 20 years, more than 60 million people have been infected with the virus. […]

VAGINAL FORMULATION – HOW INNOCUOUS ARE THEY TO THE VAGINAL EPITHELIAL IMMUNE FUNCTION?

This study by researchers in the Harvard Medical School Dept. of Obstetrics and Gynecology demonstrated that Mattek’s EpiVaginal in vitro human cervico-vaginal tissue equivalent is an excellent tissue model for […]

BIOCOMPATIBILITY OF SOLID DOSAGE ANTI-HIV-1 MICROBICIDES AND VAGINAL PRODUCTS WITH THE MUCOSAL CYTOKINE NETWORK.

IRRITATION TESTING OF CONTRACEPTIVE AND FEMININE-CARE PRODUCTS USING EPIVAGINAL, AN IN VITRO HUMAN VAGINAL-ECTOCERVICAL TISSUE MODEL.

ORGANOTYPIC ECTOCERVICO-VAGINAL TISSUE MODEL CONTAINING DENDRITIC CELLS.

Acquired immunodeficiency syndrome (AIDS) is now the fourth most common cause of death worldwide. In the last 20 years, more than 60 million people have been infected with the virus. […]

A HUMAN ORAL TISSUE MODEL TO EVALUATE TOXICITY AND ANTI-HIV ACTIVITY OF THE SPERMICIDE-MICROBICIDE, NONOXYNOL-9M.

This study by researchers at the University of Washington, the Fred Hutchinson Cancer Research Center and Mattek Corp. demonstrated that a new form of Mattek’s EpiOral full thickness human buccal […]