Skip to Main Content
+1 (508) 881-6771
0
Menu Button

Microbicide

577

SAFETY TESTING OF SILICONE ELASTOMER MATRIX VAGINAL RINGS CONTAINING UC781 AND TWEEN 80 USING EPIVAGINAL(VEC-606) TISSUES.

The microbicidal agent UC781 has very limited aqueous solubility. A recent study in pig-tailed macaques showed poor pharmacokinetic levels, suggesting that, unlike in vitro release testing which uses relatively large volumes of a hydroalcoholic release media, the vaginal environment does not provide equivalent solubilising power to dissolve UC781 diffused from the ring. To overcome this […]
571

A NEW MODEL FOR STUDIES ON CERVICOVAGINAL INFLAMMATION AND BARRIER DISRUPTION.

INTRODUCTION: Several microbicide candidates have failed in recent clinical trials due to the induction of vaginal inflammation and epithelial barrier disruption. New preclinical models are needed for assessing inflammation and barrier disruption of the vaginal epithelium, and for testing effects of microbicides in an inflammatory environment. OBJECTIVE: The purpose of this study was to establish […]
469

STUDIES ON VAGINAL INNATE IMMUNITY IN THE EPIVAGINAL MODEL.

This study by researchers at Boston University School of Medicine and Mattek Corp. demonstrated that the EpiVaginal full thickness human cervico-vaginal tissue equivalent can provide valuable information on molecular mechanisms of vaginal innate immunity, and serve as a test system to determine effects of microbicides on vaginal immune defense. Background: The Mattek EpiVaginal™ (EV) full […]