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Infections

856

A series of in vitro and human studies of a novel lip cream formulation for protecting against environmental triggers of recurrent herpes labialis

Purpose: These studies describe the testing of a novel, daily-use lip cream designed for individuals with lips prone to recurrent herpes labialis (RHL) that protects against environmental triggers. Subjects and methods: In vitro occlusive and in vitro and in vivo photoprotection analyses, a characterization of normal vs dry lips, and a randomized, evaluator-blinded, clinical trial […]
806

Antiviral Activity of Ribavirin, 2’,3’-Dideoxicitidine, Pirodavir, Oseltamivir and Infergen™ against RSV, Adeno-2, Rhino-14, Influenza and HCoV-EMC Infection in Differentiated Normal Bronchial Epithelial (dNHBE) Cells

The antiviral activity of ribavirin, 2’,3’-ddC, pirodavir, oseltamivir and Infergen™ was evaluated against respiratory syncytial virus (RSV), adenovirus type 2, rhinovirus type 14, influenza, and human coronavirus HCoV-EMC in a highly differentiated, three-dimensional, ex vivo model of normal human bronchial (dNHBE) cells. Antiviral activity was measured by virus yield reduction assays 3-6 days after infection in the presence of […]
680

NVC-422: TOWARDS DEVELOPING PRECLINICAL INFECTED TISSUE MODELS.

Background: P. aeruginosa and S. aureus are opportunistic human pathogens implicated in many clinical diseases of the eye and skin, including keratitis and impetigo, respectively. Infection can involve destruction of underlying tissue by toxins to exacerbate tissue damage, leading to erosive disease. Developing infected tissue models provide a platform for assessing antimicrobial efficacy and toxicity […]