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Hepatotoxicity

1082

Bioengineering of novel organotypic 3D human liver tissue model for drug-induced liver injury and toxicity studies

Background: In drug development, liver failure is the cause of approximately 30% of post marketing withdrawals of pharmaceuticals. Drug-induced liver injury (DILI) remains the leading cause of acute liver failure (ALF), accounting for approximately 15% of the cases. Materials and methods: In this study, we developed a novel human three-dimensional (3D) liver tissue model by seeding […]
1004

Bioengineering of Novel Organotypic 3D Human Liver/Hepatocyte Tissue Model for Drug Induced Liver Injury/Toxicity Studies

Development of a human primary cell-based 3D organotypic liver/hepatocyte tissue model with polarized hepatic morphology that maintains high level expression of major liver associated drug metabolizing enzymes is an attractive alternative platform to study acute and chronic liver toxicity and drug induced liver injury. In this study, we developed a human 3D hepatocyte tissue model using adult primary […]