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Dry Eye

864

Oxidative stress in corneal injuries of different origin: Utilization of 3D human corneal epithelial tissue model

The purpose of the current work was to utilize a three dimensional (3D) corneal epithelial tissue model to study dry eye disease and oxidative stress-related corneal epithelial injuries for the advancement of ocular therapeutics. Air-liquid interface cultures of normal human corneal epithelial cells were used to produce 3D corneal epithelial tissues appropriate for physiologically relevant […]
805

Molecular Mechanism of Ocular Surface Damage: Dry Eye and Wound Healing Models Using in vitro Reconstructed Human Corneal Tissues

Current methods used to investigate mechanisms of corneal wound healing (CWH) and pathogenesis of dry eye disease (DED) utilize monolayer cell cultures or animals, but there is a need for more physiologically relevant, human-based in vitro models for ocular surface research. This study utilized the EpiCorneal tissue model comprised of normal human corneal epithelial cells […]