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Drug Screening

1004

Bioengineering of Novel Organotypic 3D Human Liver/Hepatocyte Tissue Model for Drug Induced Liver Injury/Toxicity Studies

Development of a human primary cell-based 3D organotypic liver/hepatocyte tissue model with polarized hepatic morphology that maintains high level expression of major liver associated drug metabolizing enzymes is an attractive alternative platform to study acute and chronic liver toxicity and drug induced liver injury. In this study, we developed a human 3D hepatocyte tissue model using adult primary […]
1003

Development of an in vitro 3D Human Kidney Proximal Tubular Epithelial Tissue Model

​The renal proximal tubular (PT) region is the most common site for a compound-specific kidney injury. The PT region is responsible for essential kidney functions, including reabsorption of low molecular weight proteins, solutes, and glucose, secretion of acids, and clearance of administered medications. The ultimate goal of this project is to develop a novel physiologically relevant primary human kidney-cell-based […]