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Drug Screening

1082

Bioengineering of novel organotypic 3D human liver tissue model for drug-induced liver injury and toxicity studies

Background: In drug development, liver failure is the cause of approximately 30% of post marketing withdrawals of pharmaceuticals. Drug-induced liver injury (DILI) remains the leading cause of acute liver failure (ALF), […]
1004

Bioengineering of Novel Organotypic 3D Human Liver/Hepatocyte Tissue Model for Drug Induced Liver Injury/Toxicity Studies

Development of a human primary cell-based 3D organotypic liver/hepatocyte tissue model with polarized hepatic morphology that maintains high level expression of major liver associated drug metabolizing enzymes is an attractive alternative platform […]
1003

Development of an in vitro 3D Human Kidney Proximal Tubular Epithelial Tissue Model

​The renal proximal tubular (PT) region is the most common site for a compound-specific kidney injury. The PT region is responsible for essential kidney functions, including reabsorption of low molecular weight proteins, […]