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Cancer Research

1077

Large scale in vitro expansion of primary tumors from metastasis cancer patients with different mutations for preclinical drug screening

The use of patient derived primary tumors (PDPT) is becoming a powerful vitro tool in candidate cancer drug screening for safety and efficacy. Compared to 2D cell lines, the PDPTs can 1) better recapitulate the human tumor microenvironment (TME), 2) predict drug responses in humans, 3) be used in high throughput drug screening platforms to […]
1040

Novel Organotypic Patient-Derived Primary Tumor Tissues for Oncology Drug Safety and Efficacy Studies

Organotypic, three-dimensional (3D) cancer tissue models (OCTM) have enabled investigators to develop predictive markers that can be used in preclinical cancer drug development. However, a drawback of the existing models is that they are mostly cell line-based are not physiologic. In vitro development of 3D tumoroids using patient derived primary tumors (PDPT) in tumor microenvironment […]