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Basic dermal research

809

Application of Mattek In Vitro Reconstructed Human Skin Models for Safety, Efficacy Screening, and Basic Preclinical Research

During the past three decades, great progress has been achieved in the development of in vitro reconstructed human epidermal (RhE) tissue models. This technology is now available via various manufacturers of […]
557

INFLAMMATORY ACTIVITY OF PARTHENOLIDE-DEPLETED FEVERFEW (TANACETUM PARTHENIUM).

This study by researchers at Johnson and Johnson demonstrated that Mattek’s EpiDerm in vitro 3-D human skin tissue equivalent can be used to measure the effectiveness of a new topical […]
553

THE EFFICACY OF ECHINACEA IN A 3-D TISSUE MODEL OF HUMAN AIRWAY EPITHELIUM.

This study by researchers at the University of British Columbia and A. Vogel Bioforce AG demonstrated that Mattek’s EpiAirway in vitro 3-D human tracheal/bronchial tissue equivalent can be infected with […]
463

CHARACTERIZATION OF THE EFFECT OF URINE ON MECHANICALLY INDUCED SKIN DAMAGE.

As stated in the “Conclusions” section, the main experiment in this study by researchers at Eindhoven University of Technology was performed to determine whether urine makes the skin more susceptible […]
462

CYTOKINE AND CHEMOKINE RELEASE UPON PROLONGED MECHANICAL LOADING OF THE EPIDERMIS.

This study by researchers at the Eindhoven University of Technology and the VU University Medical Center Dept. of Dermatology demonstrated that Mattek’s EpiDerm human epidermal tissue equivalent can be used […]
538

EXPRESSION OF STRATUM CORNEUM LIPID PATHWAYS IN HUMAN SKIN EQUIVALENT CULTURES.

This study by scientists at Procter & Gamble Beauty demonstrated that gene pathways involved in stratum corneum lipid formation are expressed in Mattek’s EpiDermFT full-thickness in vitro 3-D human skin […]
194

XENOBIOTIC METABOLISM GENE EXPRESSION IN THE EPIDERM™ IN VITRO 3D HUMAN EPIDERMIS MODEL COMPARED TO HUMAN SKIN.

There is an urgent need to validate in vitro human skin models for use in safety testing. An important component of validation is characterizing the metabolizing capacity of these models. […]
604

PROTECTIVE EFFECT OF POMEGRANATE-DERIVED PRODUCTS ON UVB-MEDIATED DAMAGE IN HUMAN RECONSTITUTED SKIN.

Solar ultraviolet (UV) radiation, particularly its UVB (290–320 nm) component, is the primary cause of many adverse biological effects including photoageing and skin cancer. UVB radiation causes DNA damage, protein […]
605

THE COLIPA SKIN METABOLISM PROJECT: DO IN VITRO ALTERNATIVES COMPRISE ADEQUATE DETOXIFICATION CAPACITIES FOR CHEMICAL TESTING IN SKIN?

Background: The aim of this study is to characterize the specific enzymatic activity of Phase I and II detoxification enzymes in human ex vivo skin compared to skin cell-derived in […]
603

INTERNATIONAL PREVALIDATION STUDIES OF THE EPIDERM™ 3D HUMAN RECONSTRUCTED SKIN MICRONUCLEUS (RSMN) ASSAY: TRANSFERABILITY AND REPRODUCIBILITY.

Recently, a novel in vitro reconstructed skin micronucleus (RSMN) assay incorporating the EpiDermTM 3D human skin model (Curren et al., Mutat. Res. 607 (2006) 192–204; Mun et al., Mutat. Res. […]
602

INCREASED HYALURONAN PRODUCTION AND DECREASED E-CADHERIN EXPRESSION BY CYTOKINE-STIMULATED KERATINOCYTES LEAD TO SPONGIOSIS FORMATION.

The pathogenesis of spongiosis, which is a well-known hallmark of acute eczema, is not fully understood. We sought to clarify the mechanism for the influx of tissue fluid into the […]
547

Gamma-H2AX AS A BIOMARKER OF DNA DAMAGE INDUCED BY IONIZING RADIATION IN HUMAN PERIPHERAL BLOOD LYMPHOCYTES AND ARTIFICIAL SKIN.

This study by researchers at the National Cancer Institute (USA) demonstrated that Mattek’s EpiDermFT full-thickness in vitro 3-D human skin tissue equivalent is an excellent tissue model for performing experiments […]
541

REGULATION OF TIGHT JUNCTION PERMEABILITY BY SODIUM CAPRATE IN HUMAN KERATINOCYTES AND RECONSTRUCTED EPIDERMIS.

This study by researchers at Pola Chemical Industries Inc. and Jikei University School of Medicine used Mattek’s EpiDerm in vitro 3-D human skin tissue equivalent to investigate the effects of […]
536

THE TRANSPORT PROFILE OF CYTOKINES IN EPIDERMAL EQUIVALENTS SUBJECTED TO MECHANICAL LOADING.

This study by researchers at Eindhoven University of Technology and the University of London demonstrated how Mattek’s EpiDerm in vitro 3-D human skin tissue equivalent can be used to study […]
466

AN IN VITRO MODEL SYSTEM TO STUDY THE DAMAGING EFFECTS OF PROLONGED MECHANICAL LOADING OF THE EPIDERMIS.

This study by scientists at the Eindhoven University of Technology demonstrated that Mattek’s EpiDerm human skin tissue equivalent can be used to improve insight in the epidermal damage process due […]
465

SUNSCREEN ENHANCEMENT OF UV-INDUCED REACTIVE OXYGEN SPECIES IN THE SKIN.

This study by scientists at UC Riverside and UC Irvine demonstrated that two-photon fluorescence microscopy can be successfully used to image UV-induced ROS generation in both ex vivo skin and […]
638

DYNAMIC AND PHYSICAL CLUSTERING OF GENE EXPRESSION DURING EPIDERMAL BARRIER FORMATION IN DIFFERENTIATING KERATINOCYTES.

The mammalian epidermis is a continually renewing structure that provides the interface between the organism and an innately hostile environment. The keratinocyte is its principal cell. Keratinocyte proteins form a […]
975

TRANSCUTANEOUS IMMUNIZATION USING COMMON CHEMICALS.

Transcutaneous immunization, topical application of vaccines on skin, provides several advantages over needle based immunization. However, simple topical application of vaccines does not generate sufficient immune response due to limited […]
606

DIFFUSION MEASUREMENTS IN EPIDERMAL TISSUES WITH FLUORESCENT RECOVERY AFTER PHOTOBLEACHING.

Background/Purpose: Pressure ulcers are areas of soft tissue breakdown, resulting from sustained mechanical loading of the skin and underlying tissues. Measuring biochemical markers that are released upon mechanical loading by […]
554

REGULATION OF APOPTOSIS BY P53 IN UV-IRRADIATED HUMAN EPIDERMIS, PSORIATIC PLAQUES AND SENESCENT KERATINOCYTES.

This study by researchers at Loyola University Medical Center demonstrated that Mattek’s EpiDerm in vitro 3-D human skin tissue equivalent can be used to study the sensitivity and resistance of […]