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Basic DC research

502

GENE EXPRESSION ANALYSIS OF DENDRITIC/LANGERHANS CELLS AND LANGERHANS CELL HISTIOCYTOSIS.

This study by researchers in the departments of Pathology and Laboratory Medicine, and Pediatric Oncology at the University of Groningen demonstrated that Mattek’s Human Langerhans/Dendritic Cells are an excellent in vitro model for studying the gene expression of Langerhans cell histiocytosis (LCH). Langerhans cell histiocytosis (LCH) is a neoplastic disorder that results in clonal proliferation […]
477

COLCHICINE PROMOTES ANTIGEN CROSS-PRESENTATION BY MURINE DENDRITIC CELLS.

This study by researchers at the University of Texas Southwestern Medical Center demonstrated that Mattek’s Human Langerhans/Dendritic Cells are an excellent in vitro model for investigating and predicting the likely interactions of drugs (Colchicine) with human dendritic cells. Colchicine (COL) is a microtubule depolymerizing drug that has been widely used for the treatment of many […]
475

NOREPINEPHRINE MODULATES HUMAN DENDRITIC CELL ACTIVATION BY ALTERING CYTOKINE RELEASE.

This study by researchers at Weill Medical College of Cornell University and Clinique Laboratories demonstrated how Mattek’s Human Dendritic Cells can be used to observe the effect of a specific compound (norepinephrine) on the cytokine expression of cells that are central to the immune response in human skin. Norepinephrine (NE) can modulate dendritic cell (DC) […]
779

The impact of dietary fibers on dendritic cell responses in vitro is dependent on the differential effects of the fibers on intestinal epithelial cells

SCOPE: In the present study, the direct interaction of commonly consumed fibers with epithelial or dendritic cells (DCs) was studied. METHODS AND RESULTS: The fibers were characterized for their sugar composition and chain length profile. When in direct contact, fibers activate DCs only mildly. This was different when DCs and fibers were co-cultured together with […]
748

EPSTEIN-BARR VIRUS ENCODED DUTPASE CONTAINING EXOSOMES MODULATE INNATE AND ADAPTIVE IMMUNE RESPONSES IN HUMAN DENDRITIC CELLS AND PERIPHERAL BLOOD MONONUCLEAR CELLS.

We have recently demonstrated that Epstein-Barr virus (EBV)-encoded deoxyuridine triphosphate nucleotidohydrolase (dUTPase) modulates innate immunity in human primary monocyte-derived macrophages through toll-like receptor (TLR) 2 leading to NF-KB activation and the production of pro-inflammatory cytokines. Our previous depletion studies indicated that dendritic cells (DCs) may also be a target of the EBV-encoded dUTPase. However, the […]
741

ATTENUATION OF NIACIN-INDUCED PROSTAGLANDIN D2 GENERATION BY OMEGA-3 FATTY ACIDS IN THP-1 MACROPHAGES AND LANGERHANS DENDRITIC CELLS.

Niacin, also known as nicotinic acid, is an organic compound that has several cardiobeneficial effects. However, its use is limited due to the induction of a variable flushing response in most individuals. Flushing occurs from a niacin receptor mediated generation of prostaglandins from arachidonic acid metabolism. This study examined the ability of docosahexaenoic  acid, eicosapentaenoic […]
721

HUMAN INTESTINAL DENDRITIC CELLS DECREASE CYTOKINE RELEASE AGAINST SALMONELLA INFECTION IN THE PRESENCE OF LACTOBACILLUS PARACASEI UPON TLR ACTIVATION.

Probiotic bacteria have been shown to modulate immune responses and could have therapeutic effects in allergic and inflammatory disorders. However, little is known about the signaling pathways that are engaged by probiotics. Dendritic cells (DCs) are antigen-presenting cells that are involved in immunity and tolerance. Monocyte-derived dendritic cells (MoDCs) and murine DCs are different from […]
675

ASSURING SAFETY WITHOUT ANIMAL TESTING: DEVELOPMENT OF MECHANISTIC UNDERSTANDING OF DENDRITIC CELL ACTIVATION RESPONSE TO CHEMICAL SENSITISERS.

Assuring consumer safety without the generation of new animal data is currently a considerable challenge but one that we believe is ultimately achievable. Skin allergy (sensitisation) is an important consumer safety endpoint for home and personal care products and an endpoint where animal data (e.g. mouse local lymph node assay data) are often needed to […]