artificial saliva

Comparative evaluation of artificial saliva and complete artificial saliva as solvent vehicles for in vitro toxicity testing of oral tobacco products

Oral tobacco-derived nicotine (OTDN) pouches are tobacco-free products and are considered potential reduced-risk alternatives to traditional tobacco products within the tobacco harm reduction framework. Despite their growing popularity, the local oral toxicity profiles of OTDNs remain poorly characterized. Although in vitro toxicity studies have been conducted, the lack of standardized testing protocols, including solvent vehicle selection, limits […]