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Anti-aging

985

Anti-Glycation and Anti-Aging Properties of Resveratrol Derivatives in the in-vitro 3D Models of Human Skin

Purpose: Human skin undergoes modifications affecting its structural properties and barrier functions involved in protection against age-related damage. Glycation is a non-enzymatic reaction between macromolecules and sugars causing alterations to the elastic fibers and premature aging of the skin. Glycation can be prevented by a range of bioactive molecules; however, at present only a few […]
981

The soybean cultivar SCEL‑1 shows potent anti‑photoaging effects in a UV‑induced three‑dimensional human skin and hairless mouse model

Soybean (Glycine max) is one of the major sources of nutrition and is used as a raw material for food and as a source of feed for livestock. The efficacy of soybeans on skin health includes their ability to reduce wrinkles and pigmentation and increase skin elasticity and moisture content. Black soybean has been consumed […]
977

Anti-aging Effects of Retinoid Hydroxypinacolone Retinoate on Skin Models

Tretinoin, also known as all-trans retinoic acid (ATRA), has been well-known for its anti-aging effects on skin since the 1980s.1,2 ATRA functions by activating the nuclear retinoic acid family of receptors (RARs), which control gene transcription by binding to retinoic acid responsive elements (RAREs) in DNA.3 Retinoids are thought to reduce wrinkles by increasing type […]
976

2-kDa hyaluronan ameliorates human facial wrinkles through increased dermal collagen density related to promotion of collagen remodeling

Background/Aims: Hyaluronan (HA) oligosaccharides are involved in several biological processes, primarily collagen remodeling and wound healing. Collagen remodeling is retarded in aging skin and causes wrinkles. The aim of this study was to evaluate the effect of 2-kDa HA oligosaccharides (HA2k) on wrinkles by permeation through the stratum corneum and promotion of collagen remodeling. Methods: […]
869

Coumestrol Down-Regulates Melanin Production in Melan-a Murine Melanocytes through Degradation of Tyrosinase

Pigmentation reflects skin darkening caused by melanin production, but excessive melanin synthesis may cause problems, such as melasma, solar lentigo, dark spots, and freckles. Considerable effort has been devoted to alleviating these undesired symptoms through the development of safe and effective depigmenting agents. Coumestrol, a plant-derived natural isoflavone with an estrogen-like structure and actions, is […]
795

Total Defense + Repair: A Novel Concept in Solar Protection and Skin Rejuvenation

For more than a century, solar radiation has been known to contribute Significantly to the extrinsic aging of skin. Until recently, this was almost exclusively attributed to the photodamage caused by ultraviolet (UV) light. However, a growing body of evidence now indicates that both infrared (IR) and visible light may also contribute to extrinsic skin aging. Infrared […]
634

UNDERSTANDING METABOLIC PATHWAYS FOR SKIN ANTI-AGING.

Global gene expression profiling provides a useful means to identify key aspects of the skin aging process, and provides Information to help develop new skin technologies. Important aspects of skin aging that can be addressed Include skin hydration, barrier, matrix, pigmentation and antioxidant capacity. Human skin equivalent cultures allow topical application of test compounds, combinations […]
510

TOPICAL N-ACETYL GLUCOSAMINE AND NIACINAMIDE INCREASE HYALURONAN IN VITRO.

This study by researchers at Procter & Gamble Co. demonstrated how Mattek’s EpiDermFT full-thickness in vitro human skin tissue equivalent can be used to study the expression of a major extracellular matrix component of human skin (hyaluronan) when N-acetyl glucosamine and niacinamide are applied to the apical surface of the tissues simulating topical application on […]
157

IN VITRO SCREENING TECHNIQUES IN DERMATOLOGY.

To avoid skin irritation and allergies from cosmetic products, the raw materials should be screened during product development. In vivo screening techniques are best. The author describes two in vitro models (cell culture and living skin equivalent) and several in vitro tests (percutaneous absorption, toxicity, melanogenesis, wound healing, antiaging, and cell proliferation and differentiation).
595

DC DETOXDEFENSE™ STIMULATES SKIN’S OWN SOD ANTIOXIDANT PROTECTION AND DETOXIFICATION.

Objective: The objective of this experiment was to determine whether the results previously obtained DC Detoxdefense in enzymatic and cell-based assays are corroborated by modulation of gene expression in EpiDerm human skin substitute model. Methods: EpiDerm tissues were obtained from Mattek (Ashland, MA) and cultured according to the manufacturer’s instructions. The test materials – Upregulex […]
539

ANTIOXIDANT CAPACITY OF 3D HUMAN SKIN EPIDERM MODEL: EFFECTS ON SKIN MOISTURIZERS.

This study by researchers at North Dakota State University, the University of North Dakota and the Plastic Surgery Institute demonstrated how Mattek’s EpiDerm in vitro 3-D human skin tissue equivalent can be used to better understand the mechanisms of the effects of skin moisturizers containing antioxidant ingredients on skin function at the tissue level, and […]
385

USE OF EPIDERM FULL THICKNESS TISSUE FOR ANTI-AGING STUDIES.

This study by scientists at Arch Personal Care Products demonstrated that Mattek’s EpiDermFT full-thickness in vitro human skin tissue equivalent can be used to measure the effect of a new topically applied formulation on the elastin content in human skin’s extracellular matrix. Mattek’s EpiDerm and EpiOcular in vitro tissues were also used to show this […]
738

PROTECTION AND REPAIR OF SKIN DAMAGE FROM ENVIRONMENTAL AGGRESSORS.

There is an increasing awareness that environmental factors, such as UV, cigarette smoke, pollution, and extreme temperatures can lead to skin aging. The mechanisms underlying this extrinsic aging effect remain uncertain. Previous studies showed that one of the negative actions from UV and smoke was oxidative damage. Here, we show that each of the aggressors […]
737

BIOLOGICAL FUNCTION & MODULATION OF THYMOSIN β4 IN HUMAN SKIN.

Thymosin beta 4 (Tb4) belongs to a highly conserved, water-soluble, acidic polypeptide family of proteins1. Although it was originally identified as an actin-sequestering molecule in eukaryotic cells, Tb4 plays a critical role in dermal and corneal wound healing via multiple activities: anti-inflammatory, stimulation of keratinocyte migration, regulating MMP expression, and matrix remodeling2, 3, 4. Age-related […]
736

ENCAPSULATED RETINOL (0.5%) AND RETINOIC ACID (0.05%) ARE EQUALLY EFFECTIVE AT PROTECTING AGAINST UV-INDUCED DAMAGE IN EPIDERM-FT TISSUES.

Solar ultraviolet light damages skin resulting in photoaging which superimposed on chronological aging resulting in worsening of skin appearance. The extent of sun damage is proportional to the amount/time of UV-light exposure triggering visible changes such as dryness, rough texture, irregular pigmentation, telangiectasia, plaque-like thickening, deep creases and fine wrinkles. Both epidermis and dermis are […]
735

DIFFERENTIAL MODULATION OF ECM COMPONENTS AND GFR BY RETINOIC ACID AND A PHYSIOLOGICALLY BALANCED GF FORMULATION.

Overall appearance of skin is a combination of health, ethnicity, lifestyle and age, which determine skin color, texture, firmness and smoothness. Uneven color, rough, lax and wrinkled skin are associated with aged skin. Microscopically, aged skin has an atrophic epidermis, flattened dermal-epidermal junction, decreased number of dermal fibroblasts and diminished synthesis of extracellular matrix components […]
723

BIOCHEMICAL INVESTIGATION AND GENE ANALYSIS OF EQUOL: A PLANT AND SOY-DERIVED ISOFLAVONOID WITH ANTIAGING AND ANTIOXIDANT PROPERTIES WITH POTENTIAL HUMAN SKIN APPLICATIONS.

The purpose of this study was to investigate the effects of equol, a plant and intestinal flora derived isoflavonoid molecule on the expression of skin genes and proteins using human dermal models. As equol has been shown to mimic 17β-estradiol and bind specifically to 5α-dihydrotestosterone (5α-DHT), these agents were used (in addition to equol) to […]
518

IN VITRO SKIN BIOMARKER RESPONSES TO A NEW ANTI-AGING PEPTIDE, PAL-KT.

This study by scientists at Procter & Gamble (P&G Beauty Div.) and Sederma demonstrated that Mattek’s EpiDermFT full-thickness in vitro human skin tissue equivalent is an excellent in vitro model for screening novel peptides for their potential anti-aging effects on facial skin. Peptides applied topically in moisturizer-type cosmetic products are known to improve the appearance […]
488

STIMULATION OF EPIDERMAL HYALURONAN BY YEAST FERMENT.

This study by researchers at Procter & Gamble Co. demonstrated how Mattek’s EpiDermFT full-thickness in vitro human skin tissue equivalent can be used to study the expression of a major extracellular matrix component of human skin (hyaluronan), and can also be used to trace hyaluronan expression to cells in the epidermal layer. INTRODUCTION: Hyaluronan is […]
460

EVALUATION OF COSMETIC INGREDIENTS IN TISSUE ENGINEERED HUMAN SKIN IN VITRO.

This study by scientists at Procter & Gamble demonstrated that Mattek’s MelanoDerm and EpiDermFT in vitro human skin equivalent tissues are useful tools in understanding how compounds used in anti-aging cosmetic products (“cosmeceuticals”) like N-acetyl glucosamine and niacinamide affect production of important skin matrix components including collagen. Introduction: As part of Procter & Gamble’s ongoing […]
549

AccelaFuze™ PEPTIDE INFUSION THERAPY.

This study by scientists at Woodford Medical Aesthetics demonstrated that Mattek’s EpiDermFT full-thickness in vitro 3-D human skin tissue equivalent, because it is produced from normal (non-transformed) human skin cells (keratinocytes and fibroblasts), can be used to accurately measure the specific gene expression changes produced by new topical skin treatments before they are tested on […]