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Applications & Services

HUREL Micro Liver Services

Cytotoxicity-Hepatotoxicity Screen DILItrain™

Our cytotoxicity and hepatotoxicity screening service makes early, high-acuity assessment of hepatotoxic risk cost-effective and thereby brings new illumination to the challenge of reducing late-stage candidate attrition.

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HUREL® Flux™ Service

Hepatobiliary research services based on a new, patent-pending efflux transporter assay method. Transporters can play an important role in the clearance and excretion of the parent drug and/or its metabolite(s) into the bile canaliculus.

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Metabolic Clearance

The HUREL micro liver coculture system is a robust and reliable method for human in vivo clearance prediction and metabolite detection of slowly metabolized drugs.

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Metabolite Generation and ID

HUREL micro livers produce robust metabolite yields that closely correlate to metabolites generated by parent compounds in vivo.

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Multi-Parameter Toxicity-HUREL Tox™

Our Multi-Parameter Toxicity assay’s apply HUREL’s superior metabolic competency to a panel of complementary assays, creating a multi-parametric characterization of hepatotoxic risk.

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Reaction Phenotyping Assay

Using HURELhumanPool™ primary hepatocyte micro liver model, intrinsic clearance rates for parent drug depletion in the absence and the presence of CYP inhibitors are measured to determine the contribution of CYP enzymes.

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Viral Liver Disease Modeling-HUREL Viral™

The HUREL Viral™ platform aids the study of viral persistence and accelerates the development of antiviral drugs.

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OUR PRODUCT AT A GLANCE

HUREL® Micro Livers are self-assembling co-cultures (SACCs) of primary hepatocytes. This patented form of liver cell culture has been demonstrated to produce the longest-enduring, most phenotypically stable and metabolically competent of any liver tissue construct developed in the world to date.

Metabolic Competency

The HUREL Micro Liver’s superior metabolic competency, derived in part from their multi-fold greater hepatocyte number and therefore greater cell density within the microtiter well, is the characteristic most centrally responsible for HUREL’s delivering data of superior translational predictivity for DMPK studies.

Phenotypically Stable

Rock-solid, long-enduring phenotypic stability creates the foundation for the superior metabolic competency that distinguishes data generated on the HUREL platform from that of primary hepatocytes cultured in suspension, in monoculture, in micropatterned arrays, and in 3D spheroids.

Peer Reviewed & Validated

The HUREL micro liver models have been used in dozens of publications to date by the world’s leading pharmaceutical companies and are integral to services at many contract research organizations.

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