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Dendritic Cells

EpiAirway^TM

EpiDerm^TM

EpiDermFT^TM

EpiOcular^TM

EpiOral^TM

EpiVaginal^TM

MelanoDerm^TM

Melanoma



MatTek Corporation
200 Homer Avenue
Ashland, MA  01721
508-881-6771
FAX:  508-879-1532
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In Vitro Applications by Product

• In Vitro TISSUE Model Basics (Tutorial)
  
  
• In Vitro Toxicology Applications
  
  
• Normal Human Cell-Based In Vitro Epithelial Models for Drug Delivery and Toxicology Applications - MatTek presentation made at the Tissue Models for Drug Discovery conference (Powerpoint presentation, PDF file, 1.65 MB). Major sections:
  • Basic Technique for Reconstituting 3-D Organotypic Epithelial Tissues
  • Survey of Normal Human Cell-Based Epithelial Models Produced at MatTek Corporation
  • ADME/TOX Applications of an Organotypic Normal Human Airway Epithelial Model
  
  
• EpiAirway Tissues - Application Examples
  Drug Delivery * Pharmacology/Toxicology * Asthma Research * COPD Research * Respiratory Infection * Inhalation Toxicology * Tobacco Smoke Analysis * Nanotoxicology * High Throughput Screening (HTS)
  
  
• EpiDerm Tissues - Application Examples
  Skin Irritation * Dermal Corrosion * Phototoxicity * Inflammation * Percutaneous Absorption * Transdermal Drug Delivery * Psoriasis Research * High Throughput Screening (HTS) * Long-Term Reproducibility
  
  
• EpiDermFT Tissues - Application Examples
  EpiDermFT vs. EpiDerm * Toxicology & Drug Development * Wound Healing * Skin Cancer * Photodamage * Photoaging * Anti-Aging * Radiation Damage * Blistering Skin Diseases * Genetic Damage
  
  
• EpiOcular Tissues - Application Examples
  Draize Test Alternative * "Sub-Draize" Ocular Irritation Testing * Long Term Reproducibility * Ocular Irritation of: Surfactants - Consumer Products - "Air Care" Products - Cosmetic Eye Products
  
  
• EpiOral/EpiGingival Tissues - Application Examples
  Transmucosal Drug Delivery * Buccal Drug Delivery * Gingivitis * Gum Disease * Oral Cancer * Oral Mucosa * Smokeless Tobacco Effects * Oral Epithelia Proliferation * Antimicrobial Barrier Function * Mucosal Irritation * Oral Irritation Potential of: Dentifrice Formulations - Mouthwashes - Toothpastes - Oral Cleansers
  
  
• EpiVaginal Tissues – Application Examples
  Microbicide Toxicity, Efficacy * Contraceptive Product Irritation * Feminine Hygiene Product Irritation * Vaginal Care Product Irritation * HIV-1 Infection * Sexually Transmitted Disease (STD) Infection * Vaginal Drug Delivery
  
  
• MelanoDerm Tissues – Application Examples
  Skin Lightening-Darkening Experiments * Skin Pigmentation Modulation * Melanogenesis * Cosmetics, Pharmaceuticals Evaluations * Keratinocyte-Melanocyte Interactions
  
  
• Dendritic Cells - Application Examples
  Allergenicity Studies * Microbial Infection/Transmission * Antigen Binding/Presentation * Innate Immunity * Immuno-therapy * Allogeneic T-Cell Proliferation * Autologous T-Cell Proliferation * HIV-1 Infection
  
  

"Ready-to-Use" TISSUE Basics:

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