• In Vitro TISSUE Model Basics (Brief Overview)
  
  
• In Vitro Toxicology Applications
  
  
• In Vitro Technical References Indexed by Application
  
  
• Normal Human Cell-Based In Vitro Epithelial Models for Drug Delivery and Toxicology Applications - MatTek presentation made at the Tissue Models for Drug Discovery conference (Powerpoint presentation, PDF file, 1.65 MB). Major sections:
  • Basic Technique for Reconstituting 3-D Organotypic Epithelial Tissues
  • Survey of Normal Human Cell-Based Epithelial Models Produced at MatTek Corporation
  • ADME/TOX Applications of an Organotypic Normal Human Airway Epithelial Model

Applications by Product

• EpiAirway Tissues - Application Examples
  Inhaled Drug Delivery * Asthma/COPD Research * Respiratory Infection * Tobacco Smoke/Nano-particle Toxicology * Inhalation Toxicology/Genotoxicology * Respiratory Allergy/Immunology * High Throughput Screening (HTS)...
  
  
• EpiDerm Tissues - Application Examples
  Skin Irritation * Dermal Corrosion * Phototoxicity * Inflammation * Percutaneous Absorption/Penetration * Transdermal Drug Delivery * Psoriasis Research * High Throughput Screening (HTS) * Long-Term Reproducibility...
  
  
• EpiDermFT Tissues - Application Examples
  Comparison: EpiDermFT vs. EpiDerm * Toxicology & Drug Development * Wound Healing * Skin Cancer * Photodamage * Photoaging * Anti-Aging * Radiation Damage * Blistering Skin Diseases * Genetic Damage...
  
  
• EpiOcular Tissues - Application Examples
  Ocular Irritation Determination * “Sub-Draize” Mild, Milder, Mildest Ocular Irritation Testing * Draize Score Determination for Surfactants and Surfactant-based Products (Cosmetics, Consumer Products, etc.)...
  
  
• EpiOral/EpiGingival Tissues - Application Examples
  Mucosal and Oral Irritation * Transmucosal and Buccal Drug Delivery * Gingivitis * Gum Disease * Oral Cancer * Smokeless Tobacco Effects * Oral Epithelia Proliferation * Antimicrobial Barrier Function * Oral Irritation Potential of: Dentifrice Formulations - Mouthwashes - Toothpastes - Oral Cleansers...
  
  
• EpiVaginal Tissues – Application Examples
  Microbicide Toxicity/Efficacy * Feminine Hygiene/Contraceptive Product Irritation * HIV-1 Infection * Sexually Transmitted Disease (STD) Infection * Vaginal Drug Delivery * Innate Immunity * Cell Adhesion…
  
  
• MelanoDerm Tissues – Application Examples
  Skin Lightening-Darkening Experiments * Skin Pigmentation Modulation * Melanogenesis * Cosmetics, Pharmaceuticals Evaluations * Keratinocyte-Melanocyte Interactions...
  
  
• Dendritic Cells - Application Examples
  Allergenicity Studies * Microbial Infection/Transmission * Antigen Binding/Presentation * Innate Immunity * Immuno-therapy * Allogeneic T-Cell Proliferation * Autologous T-Cell Proliferation...